Wikipedia

Outline of immunology

The following outline is provided as an overview of and topical guide to immunology:

Immunology – study of all aspects of the immune system in all organisms.[1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

Essence of immunology edit

Immunology

  1. Branches of immunology:

1. General Immunology 2. Basic Immunology 3. Advanced Immunology 4. Medical Immunology 5. Pharmaceutical Immunology 9. Clinical Immunology 6. Environmental Immunology 8. Cellular and Molecular Immunology 9. Food and Agricultural Immunology

History of immunology edit

History of immunology

General immunological concepts edit

  • Immunity against:

Components of the immune system edit

Immune system

  Adaptive immune system edit

Adaptive immune system

  • Kinds of antibodies
  • Classification
  • Functions
  • Regions

  Innate immune system edit

Innate immune system

  • Positive
  • Negative

Organs of the immune system edit

Lymphatic system

  Primary lymphoid organs edit

Primary lymphoid organs

  Secondary lymphoid organs edit

Secondary lymphoid organs

Cells of the immune system edit

White blood cells

  Myeloid cells edit

Main articles: Myeloid cells and Phagocytes
See also: Sentinel cell

  Lymphoid cells edit

Lymphoid cells

  Others edit

(Non-hematopoietic cells with immune functions)

  Hematopoiesis edit

Main articles: Hematopoiesis and Hematopoietic stem cell
See also: Leukopoiesis, Extramedullary hematopoiesis, and Cellular differentiation

Molecules of the immune system edit

Immune receptors edit

Main articles: Immune receptor and co-receptors
See also: List of immune receptors

   Antigen receptors edit

  • Stimulatory
  • Inhibitory
  • Accessory molecule (CD79)
  • Co-receptors
  • Accessory molecules

   Pattern recognition receptors (PRRs) edit

Pattern recognition receptor

See also: List of pattern recognition receptors
See also: Pathogen-associated molecular pattern and Damage-associated molecular pattern
See also: C-type lectin
  • Dectin 1 subfamily
  • DCIR subfamily
  • Class A - Trimers
  • Class B - Two transmembrane domains
  • Others
  • NLRA (A for acidic transactivating domain)
  • NLRX

   Complement receptors edit

Complement receptor

   Fc receptors edit

Fc receptor

See also: List of Fc receptors
  • Secreted Fc receptors

   Cytokine receptors edit

Cytokine receptor

See also: List of cytokine receptors
  • Others
  • EPOR (Erythropoietin receptor) - Homodimer
  • G-CSFR (CD114) - Homodimer upon ligand binding
  • MPL (CD110, Thrombopoietin receptor) - Homodimer upon ligand binding
  • GHR (Growth hormone receptor) - Homodimer upon ligand binding
  • PRLR (Prolactin receptor)
  • Interleukin receptors

   Natural killer cell receptors edit

Natural killer cell receptors

  • Activating KIRs
  • Two domains, long cytoplasmic tail
  • Two domains, short cytoplasmic tail
  • Three domains, long cytoplasmic tail
  • Three domains, short cytoplasmic tail

   Others edit

Antibodies edit

Antibodies

Cytokines edit

Cytokine

See also: Proinflammatory cytokine, Monokine, and Lymphokine
See also: Chemotaxis
  • CX3CL1 (Fractalkine, Neurotactin)

MHCs edit

Major histocompatibility complex

See also: Human leukocyte antigen

Complement proteins edit

  • Early stage (divided by pathway)
  • Middle stage
  • Late stage
  • Complement pathway inhibitors

Antimicrobial peptides edit

Antimicrobial peptides

Transcription factors edit

  • T-bet - TH1 differentiation
  • GATA3 - TH2 differentiation
  • RORγT - TH17 differentiation
  • BCL6 - TFH differentiation
  • FoxP3 - Treg differentiation

Signaling pathways edit

Cell adhesion molecules (CAMs) edit

Cell adhesion molecules

See also: List of cell adhesion molecules
  • Alpha subunits
  • Beta subunits
  • Dimers
  • Cytoadhesin receptor
  • Leukocyte-adhesion receptor:
  • Very late antigen receptor:
  • Others

Others edit

  • CD28 - Expressed by T Cells
  • CD278 (ICOS) - Homodimer, expressed by T Cells
  • CTLA-4 (CD152)
  • PD-1 (CD279)

Immune system disorders edit

Immune disorder

Hypersensitivity and Allergy edit

Main articles: Hypersensitivity, Autoimmunity, and Autoimmune disease
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • GVHD (Graft-versus-host disease)
  • Unknown/Multiple types
  • Foreign
  • Autoimmune

Immunodeficiency edit

Immunodeficiency

See also: Immunocompetence

Cancers of the immune system edit

Myeloid diseases edit

Inflammatory diseases edit

Immunoproliferative immunoglobulin disorders edit

Immunoproliferative immunoglobulin disorders

Lymphatic organ disease edit

Immunologic techniques and tests edit

Immunology and health edit

Immunologists edit

List of immunologists

Immunology lists edit

References edit

  1. ^ Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
  2. ^ "HGNC Gene Group: C-type lectin domain containing". Retrieved 2019-08-30.
  3. ^ Geijtenbeek TB, Gringhuis SI (July 2009). "Signalling through C-type lectin receptors: shaping immune responses". Nat. Rev. Immunol. 9 (7): 465–79. doi:10.1038/nri2569. PMC 7097056. PMID 19521399.
  4. ^ Royet J, Gupta D, Dziarski R (December 2011). "Peptidoglycan recognition proteins: modulators of the microbiome and inflammation". Nat. Rev. Immunol. 11 (12): 837–51. doi:10.1038/nri3089. PMID 22076558. S2CID 5266193.

External links edit

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