NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.[5] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.[6]
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| Aliases | NLRP14, CLR11.2, GC-LRR, NALP14, NOD5, PAN8, NLR family, pyrin domain containing 14, NLR family pyrin domain containing 14 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609665; MGI: 1924108; HomoloGene: 18531; GeneCards: NLRP14; OMA:NLRP14 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000158077 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016626 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
- ^ Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801.
Further reading
edit- Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
- Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
External links
edit- PDBe-KB provides an overview of all the structure information available in the PDB for Human NACHT, LRR and PYD domains-containing protein 14 (NLRP14)
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