NLRP9

NLRP9
Identifiers
Aliases	NLRP9, CLR19.1, NALP9, NOD6, PAN12, NLR family, pyrin domain containing 9, NLR family pyrin domain containing 9
External IDs	OMIM: 609663; MGI: 2675377; HomoloGene: 18530; GeneCards: NLRP9; OMA:NLRP9 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,738,402 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,807,231 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; testicle; ; muscle layer of sigmoid colon; ; tibial arteries; ; body of stomach; ; prostate; ; fundus; ; right coronary artery; ; body of uterus;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; jejunum; ; embryo; ; embryo; ; morula; ; colon; ; epithelium of small intestine; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; nucleotide binding; protein binding;
Cellular component	cytoplasm; inflammasome complex;
Biological process	positive regulation of interleukin-18 production; defense response to virus; pyroptosis; immune system process; inflammatory response; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	338321
	243874
	ENSG00000185792
	ENSMUSG00000060508
	Q7RTR0
	Q66X22
	NM_176820
	NM_194058
	NP_789790
	NP_918947
	Wikidata
View/Edit Human	View/Edit Mouse

NLRP9, short for NOD-like receptor family pyrin domain containing 9, is an intracellular protein that is expressed in the ovaries, testes, oocytes, and preimplantation embryos of mammals that is likely involved in reproductive processes.^[5]^[6]^[7] It is also known as NALP9, NOD6, PAN12, and CLR19.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185792 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060508 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dalbiès-Tran R, Papillier P, Pennetier S, Uzbekova S, Monget P (August 2005). "Bovine mater-like NALP9 is an oocyte marker gene". Mol. Reprod. Dev. 71 (4): 414–21. doi:10.1002/mrd.20298. PMID 15892040. S2CID 33157680.
^ Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045. S2CID 2784688.
^ Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9 (1): 202. Bibcode:2009BMCEE...9..202T. doi:10.1186/1471-2148-9-202. PMC 2735741. PMID 19682372.

Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

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