S1PR3

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.

S1PR3
Identifiers
Aliases	S1PR3, EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs	OMIM: 601965; MGI: 1339365; HomoloGene: 3829; GeneCards: S1PR3; OMA:S1PR3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.1 Start 88,990,863 bp End 89,005,155 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A5 Start 51,562,675 bp End 51,576,833 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle decidua cardiac muscle tissue of right atrium ventricular zone right ventricle right coronary artery left coronary artery tail of epididymis Descending thoracic aorta superficial temporal artery Top expressed in internal carotid artery molar left lung lobe external carotid artery dermis epithelium of lens fossa body of femur lumbar spinal ganglion abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity lipid binding integrin binding sphingosine-1-phosphate receptor activity G protein-coupled receptor activity protein binding Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane Biological process Notch signaling pathway signal transduction anatomical structure morphogenesis positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway negative regulation of establishment of endothelial barrier positive regulation of cell population proliferation sphingosine-1-phosphate receptor signaling pathway regulation of interleukin-1 beta production cytokine production inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1903 13610 Ensembl ENSG00000213694 ENSMUSG00000067586 UniProt Q99500 Q9Z0U9 RefSeq (mRNA) NM_005226 NM_010101 RefSeq (protein) NP_005217 NP_034231 Location (UCSC) Chr 9: 88.99 – 89.01 Mb Chr 13: 51.56 – 51.58 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.

Evolution

Paralogues to S1PR3 Gene

• S1PR1
• S1PR5
• S1PR2
• S1PR4
• LPAR1
• LPAR3
• LPAR2
• CNR1
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• GPR3
• MC3R
• MC2R
• GPR119
• MC1R

See also

• Lysophospholipid receptor

Further reading

• Hla T, Lee MJ, Ancellin N, et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 16–24. Bibcode:2000NYASA.905...16H. doi:10.1111/j.1749-6632.2000.tb06534.x. PMID 10818438. S2CID 19435541.
• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 54–60. Bibcode:2000NYASA.905...54S. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. S2CID 9257870.
• Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing". Ann. N. Y. Acad. Sci. 905 (1): 142–58. Bibcode:2000NYASA.905..142W. doi:10.1111/j.1749-6632.2000.tb06546.x. PMID 10818450. S2CID 9789496.
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
• Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils". Mol. Pharmacol. 49 (6): 956–61. PMID 8649355.
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
• An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733. S2CID 26300053.
• Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698.
• Zhang Q, Peyruchaud O, French KJ, et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway". Blood. 93 (9): 2984–90. doi:10.1182/blood.V93.9.2984. PMID 10216094.
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
• Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer". Cancer Res. 59 (20): 5370–5. PMID 10537322.
• Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146. S2CID 1126846.
• An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617.
• Orlati S, Porcelli AM, Hrelia S, et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor". Arch. Biochem. Biophys. 375 (1): 69–77. doi:10.1006/abbi.1999.1589. PMID 10683250.
• Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. doi:10.1152/ajpcell.2000.278.3.C612. PMID 10712250. S2CID 10976499.
• Kimura T, Watanabe T, Sato K, et al. (2000). "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3". Biochem. J. 348 (1): 71–6. doi:10.1042/0264-6021:3480071. PMC 1221037. PMID 10794715.

External links

• "Lysophospholipid Receptors: S₁P₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
• Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.