Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene .[ 5] [ 6]
FCRLA Identifiers Aliases FCRLA External IDs OMIM : 606891 ; MGI : 2138647 ; HomoloGene : 13106 ; GeneCards : FCRLA ; OMA :FCRLA - orthologs Wikidata
Receptors for the Fc fragment of IgG , or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF ). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells , leading to inflammatory responses and antibody-mediated cellular cytotoxicity . All FCGR genes map to human chromosome 1 . Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis .[supplied by OMIM][ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000132185 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038421 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol . 32 (1): 87–96. doi :10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-# . PMID 11754007 . S2CID 196599868 . ^ a b "Entrez Gene: FCRLA Fc receptor-like A" .
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