User:Fuzzform/ProjectBarb

Barbiturate

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1. Create pages for every compound in this series.
2. Finish uploading pictures to articles marked "Add image."
3. Expand upon articles as much as possible, taking into account criteria listed on WikiProject Drugs.
4. Fix problems listed below.

• All barbiturate pages should be added to the following categories, with attention to order:
  • Category:Barbiturates
  • Category:Sedatives
  • Category:Hypnotics

• Certain pages should be added to the appropriate catagory/categories below:
  • Category:Anticonvulsants
  • Category:Anesthetics
  • Category:Schedule IV controlled substances

• Add newly created barbiturate pages to main barbiturate page.

• Several barbiturates have multiple ATC codes, and this should be taken into account in the DrugBox. See the bottom of the talk page of this project for list of barbiturate ATC codes.

Barbiturates

• • Allobarbital
    • Needs drugbox
    • ATC: N05CA21
    • Several different types.

• • Amobarbital
    • Infobox incomplete.
    • Needs reorganization/cleanup.

• • Aprobarbital
    • Multiple forms of the drug; should be about the free acid form.
    • IUPAC:
    • ATC: N05 CA05
    • CAS: 77-02-1
    • Pubchem: 6464
    • DrugBank:
    • MW: 210.23 g/mol
    • MF:
    • Protein binding:
    • Metabolism:
    • Half-Life:
    • LD₅₀:
    • Overdose symptoms:
    • Classification:
    • RxList.com:
    • Inchem.org:

• • Barbexaclone (Barbexaclonum)
    • IUPAC: (2R)-1-cyclohexyl-N-methyl-propan-2-amine; 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
    • ATC: N03 AA04
    • CAS: 4388-82-3
    • Pubchem: 71196
    • DrugBank: N/A
    • MW: 387.516
    • MF: C₂₂H₃₃N₃O₃

• • Barbital
    • Needs cleanup.
    • Needs expansion.
    • Infobox incomplete.

• • Butabarbital

• • Butalbital

• • Butobarbital
    • This article is a stub.
    • Infobox incomplete.

• • Cyclobarbital
    • This article is a stub.
    • DrugBox incomplete.

• • Ethallobarbital
    • This article is a stub.
    • DrugBox incomplete.

• • Heptabarbital
    • This article is a stub.
    • DrugBox incomplete.

• • Hexobarbital
    • IUPAC: 5-(1-cyclohexenyl)- 1,5-dimethyl- hexahydropyrimidine- 2,4,6-trione
    • ATC: N05 CA16; N01 AF02
    • CAS: 56-29-1
    • Pubchem: 3608
    • DrugBank: EXPT03301
    • MW: 236.267 g/mol
    • MF: C₁₂H₁₆N₂O₃
    • Protein binding: 25%
    • Metabolism:
    • Half-Life:
    • LD₅₀:
    • Overdose symptoms:
    • Classification:
    • RxList.com:
    • Inchem.org:

• • Mephobarbital

• • Metharbital (Metabarbital)
    • IUPAC: 5,5-diethyl-1-methyl-1,3-diazinane-2,4,6-trione
    • ATC: N03 AA30
    • CAS: 50-11-3
    • Pubchem: 4099
    • DrugBank: APRD00757
    • MW: 198.219
    • MF: C₉H₁₄N₂O₃
    • Overdose symptoms: confusion, decrease in or loss of reflexes, somnolence, pyrexia, irritability, hypothermia, poor judgment, shortness of breath or slow/troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness
    • Classification: Anticonvulsants

• • Methohexital
    • Needs info on talk page to be incorporated into article.

• • Methylphenobarbital (Mephobarbital)
    • IUPAC: 5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione
    • ATC: N03 AA01
    • CAS: 115-38-8
    • Pubchem: 8271
    • DrugBank: APRD00047
    • MW: 246.262
    • MF: C₁₃H₁₄N₂O₃
    • Protein binding: 70-76%
    • Metabolism: Hepatic
    • Half-Life: 34 hours
    • Classification: Hypnotics and Sedatives, Anticonvulsants
    • RxList.com: http://www.rxlist.com/cgi/generic2/mephobarbital.htm

• • Pentobarbital
    • Infobox incomplete.
    • Needs reorganization/cleanup.

• • Phenobarbital
    • IUPAC: 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
    • ATC: N05 CA24; N03 AA02
    • CAS: 50-06-6
    • Pubchem: 4763
    • DrugBank: APRD00184
    • MW: 232.235 g/mol
    • MF: C₁₂H₁₂N₂O₃
    • Protein binding: 20-45%
    • Metabolism: Hepatic
    • Half-Life: 53 - 118 hours
    • LD₅₀:
    • Overdose symptoms:
    • Classification:
    • RxList.com:
    • Inchem.org:

• • Primidone (Mysoline)
    • Needs reorganization and factual correction.
    • Bioavailability: 90-100%
    • Protein binding: 25%
    • Metabolism: Hepatic
    • Half-Life: 3-23 hours
    • Classification: Anticonvulsants
    • RxList.com: http://www.rxlist.com/cgi/generic2/primid.htm
    • Drugs.com: http://www.drugs.com/cons/Primidone.html

• • Proxibarbal (Proxibarbital)
    • IUPAC: 5-(2-hydroxypropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
    • ATC: N05 CA22
    • CAS: 2537-29-3
    • Pubchem: 17336
    • DrugBank:
    • MW: 226.229
    • MF: C₁₀H₁₄N₂O₄
    • Protein binding:
    • Metabolism:
    • Half-Life:
    • LD₅₀:
    • Overdose symptoms:
    • Classification:
    • RxList.com:
    • Inchem.org:

• • Reposal
    • IUPAC: 5-(3-bicyclo[3.2.1]oct-3-enyl)-5-ethyl-1,3-diazinane-2,4,6-trione
    • ATC: N05 CA12
    • CAS: 3625-25-0
    • Pubchem: 19254
    • DrugBank:
    • MW: 262.304
    • MF: C₁₄H₁₈N₂O₃
    • Protein binding:
    • Metabolism:
    • Half-Life:
    • LD₅₀:
    • Overdose symptoms:
    • Classification:
    • RxList.com:
    • Inchem.org:

• • Secobarbital
    • Infobox incomplete.

• • Talbutal (permethylated butalbital)
    • IUPAC: 5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
    • ATC: N05 CA07
    • CAS: 115-44-6
    • Pubchem: 8275
    • DrugBank:
    • MW: 224.256
    • MF: C₁₁H₁₆N₂O₃
    • Protein binding:
    • Metabolism:
    • Half-Life:
    • LD₅₀:
    • Overdose symptoms:
    • Classification:
    • RxList.com:
    • Inchem.org:

• • Thiobarbital
    • This article is a stub.
    • DrugBox incomplete.

• • Thiopental (Sodium thiopental, sodium pentothal)
    • The name of the article is actually "Sodium thiopental". It should pay equal attention to both the free acid and sodium salt forms.
    • IUPAC: sodium 5-ethyl-5-(2-methylpentyl)-4,6-dioxo-1,4,5,6-tetrahydropyrimidine-2-thiolate
    • ATC: N05 CA19
    • CAS: 76-75-5
    • Pubchem: 3000714
    • DrugBank: APRD00660
    • MW: 264.321
    • MF: C₁₁H₁₇N₂NaO₂S
    • Protein binding:
    • Metabolism:
    • Half-Life: 5- 26 hours
    • LD₅₀:
    • Overdose symptoms:
    • Classification:
    • RxList.com:
    • Inchem.org:

• • Vinbarbital
    • This article is a stub.
    • Infobox incomplete.

• • Vinylbital
    • This article is a stub.
    • Infobox incomplete.

Barbiturates in combination with other drugs

• • Narcobarbital (Enibomal)
    • IUPAC: 5-(2-bromoprop-2-enyl)-1-methyl-5-propan-2-yl-1,3-diazinane-2,4,6-trione
    • ATC: N01 AG01
    • CAS:
    • Pubchem: 18735
    • DrugBank:
    • MW: 303.152
    • MF: C₁₁H₁₅BrN₂O₃
    • Bioavailability:
    • Protein binding:
    • Metabolism:
    • Half-Life:
    • Classification:

• • Tuinal (Perdormal, DEA No. 2125)
    • This drug is a combination of secobarbital and amobarbital.
    • IUPAC: disodium; 4,6-dioxo-5-pentan-2-yl-5-prop-2-enyl-1H-pyrimidin-2-olate; 5-ethyl-5-(3-methylbutyl)-4,6-dioxo-1H-pyrimidin-2-olate
    • ATC: N/A (both)
    • CAS: N/A (both)
    • Pubchem: 3080650
    • DrugBank: N/A (both)
    • MW: 508.519
    • MF: C₂₃H₃₄N₄Na₂O₆
    • Bioavailability: (both)
    • Protein binding: (both)
    • Metabolism: (both)
    • Half-Life: (both)

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