Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its potential for abuse and overdose.[1][2][3]
 | |
| Clinical data | |
|---|---|
| Pregnancy category |
|
| Routes of administration | ? |
| ATC code |
|
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Elimination half-life | ? |
| Excretion | ? |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.042.761 |
| Chemical and physical data | |
| Formula | C16H12Cl2N2O |
| Molar mass | 319.19 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
See also
editReferences
edit- ^ "Cloroqualone". PubChem. U.S. National Library of Medicine. Retrieved 2022-07-29.
- ^ Elks J (November 2014). The Dictionary of Drugs: Chemical Data. Springer US. p. 304. ISBN 978-1-4757-2085-3.
- ^ Martindale W, Reynolds JE (1993). Martindale: The Extra Pharmacopoeia (30th ed.). London: The Pharmaceutical Press. p. 745. ISBN 978-0-85369-300-0.
 | This sedative-related article is a stub. You can help Wikipedia by expanding it. |