Keerthi78

Insulin

Hi. Thanks for your contributions to the insulin article. Unfortunately the text that you added was very difficult to follow and I do not have access to the citation that you supplied. I have reproduced the text you added below and I have inserted question marks where the text is unclear. I suggest that we edit the text here before reinserting in the article. Cheers. Boghog (talk) 20:19, 11 October 2012 (UTC)

Resistance to insulin is a main drawback that explains by a single pathway in accumulation of lipid metabolites. Gathering of metabolites in ectopic lipid deposition in the liver and skeletal muscle and their activation of unfolded protein response have been included in the resistance to insulin. Most of the studies of insulin resistance related to the lipid content in tissues. Adiposomes are most preferable sites for synthesis of lipids. They have a enzymes which can access the get in and out of lipids.Protein kinase C is the only one for senstization of lipid signal and through activity of kinase that affect the cellular events and response.

Another Interesting activity is pathogenesis for insulin resistance mainly hepatic insulin. Activation of three enzymes include here:

1. Inositol enzyme ?
2. PERK enzyme (PEPCK ?)
3. Transcription factor 6. (ATF6?)

Also, I think this level of detail would be more appropriate for the insulin resistance (where the focus is on pathophysiology), not the insulin article (where the emphasis should be on physiology). Thanks. Boghog (talk) 06:34, 12 October 2012 (UTC)

Insulin therapy

Hi again. The, there are two articles, related articles, insulin and insulin therapy. The topic of the former is about the insulin protein. The later about the use of insulin to treat diabetes. The following section which you added to insulin does not belong there, but would be more appropriate for the insulin therapy article after it has been cleaned up. Boghog (talk) 05:22, 12 October 2012 (UTC)

The pharmacokinetic nature of insulin depends upon the way of administration. Here there are two types of administration one is with using Catheter and another one is using with micro needles. Catheter is a very large needle and is more painful when administered intradermally. However administration is more difficult as it is administered in such a way that right below the skin. And this method creates very fear in patients. In case of micro needle method we use a thin needle and is less painful when administered.It has fast pharmacokinetic nature and post pandrailglycemic response. Patients feel less fear and also brings glucose levels to normal glucose levels. These are the advantages of micro needle technique when compared to Catheter method. The only disadvantage of micro needle method is when piercing a small bulb is formed though it will be recovered in one day. It can be used in children as it has rapid insulin absorption.

Please use WP:MEDRS-compliant sourcing

Hello, you recently added the following source to Insulin:

<ref name="pmid21355717">{{cite journal | author = Gupta J, Felner EI, Prausnitz MR | title = Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects | journal = Diabetes Technol. Ther. | volume = 13 | issue = 4 | pages = 451–6 | year = 2011 | month = April | pmid = 21355717 | pmc = 3131988 | doi = 10.1089/dia.2010.0204 }}</ref>

This source does not meet WP:MEDRS guidelines as it is a primary study done on 5 people, and there is a clear conflict of interest with the study because the study author is selling the license to the products he used in the study. Please review WP:MEDRS, we are looking for independent reliable secondary sourcing for medical articles. Thanks... Zad68 13:40, 12 October 2012 (UTC)

Two accounts?

Do you have two editing accounts? I wonder if you understand there is no need to have two accounts, such as this one and Kanthi78. If I'm confused, please accept my apologies. If both of these accounts are yours, you may also want to read about sock puppets. -- Scray (talk) 15:07, 12 October 2012 (UTC)

Edits at Insulin

Hi, I undid this edit... I am sorry but it is unclear what you are trying to say, the source you used is WP:PRIMARY and we prefer to use secondary sourcing (see WP:MEDRS), and what you wrote does not seem to match the results the study. Can you please discuss your proposed edits on the article Talk page? Thank you... Zad68 15:37, 12 October 2012 (UTC)

October 2012

Your recent editing history at Insulin shows that you are currently engaged in an edit war. Being involved in an edit war can result in your being blocked from editing—especially if you violate the three-revert rule, which states that an editor must not perform more than three reverts on a single page within a 24-hour period. Undoing another editor's work—whether in whole or in part, whether involving the same or different material each time—counts as a revert. Also keep in mind that while violating the three-revert rule often leads to a block, you can still be blocked for edit warring—even if you don't violate the three-revert rule—should your behavior indicate that you intend to continue reverting repeatedly.

To avoid being blocked, instead of reverting please consider using the article's talk page to work toward making a version that represents consensus among editors. See BRD for how this is done. You can post a request for help at a relevant noticeboard or seek dispute resolution. In some cases, you may wish to request temporary page protection. Zad68 16:31, 12 October 2012 (UTC)

Additional edits at insulin

Concerning your latest additions to the insulin article, there are numerous problems:

1. they concern therapy and hence would better be placed on the insulin therapy article
2. they contain primary sources. Medical related material requires secondary sources per WP:MEDRS
3. they are not well integrated into the existing prose

Hence I have reverted your additions. Before attempting to re-add this material to the article, please discuss it on the article's talk page first. Thank you. Boghog (talk) 18:30, 12 October 2012 (UTC)

Notice of Edit warring noticeboard discussion

Hello. This message is being sent to inform you that there is currently a discussion involving you at Wikipedia:Administrators' noticeboard/Edit warring regarding a possible violation of Wikipedia's policy on edit warring. Thank you.

You have been blocked from editing for a period of 24 hours for edit warring, as you did at Insulin. Once the block has expired, you are welcome to make useful contributions. If you think there are good reasons why you should be unblocked, you may appeal this block by adding below this notice the text {{unblock|reason=Your reason here ~~~~}}, but you should read the guide to appealing blocks first.

During a dispute, you should first try to discuss controversial changes and seek consensus. If that proves unsuccessful, you are encouraged to seek dispute resolution, and in some cases it may be appropriate to request page protection.

The complete report of this case is at WP:AN3#User:Keerthi78 reported by User:Zad68 (Result: 24h). EdJohnston (talk) 12:55, 13 October 2012 (UTC)

Any reviewing admins should also take a look at:

• Kanthi78 (talk · contribs · deleted contribs · logs · filter log · block user · block log)
• 76.177.28.80 (talk · contribs · deleted contribs · logs · filter log · block user · block log).

These three may all be the same editor. EdJohnston (talk) 14:26, 13 October 2012 (UTC)

Since you've continued to re-add similar material at Insulin while making no effort to engage in discussion, and continued to use multiple accounts, you've been indefinitely blocked. You may be unblocked if you agree to follow Wikipedia policy. See WP:GAB for how to appeal your block. EdJohnston (talk) 21:47, 15 October 2012 (UTC)