INFO: Beginning work on ERVWE1... {November 9, 2007 10:12:36 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:13:05 AM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endogenous retroviral family W, env(C7), member 1 (syncytin)
| HGNCid = 13525
| Symbol = ERVWE1
| AltSymbols =; Env-W; HERV-7q; HERV-W; HERV-W-ENV; HERVW; env
| OMIM = 604659
| ECnumber =
| Homologene =
| MGIid =
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019028 |text = viral capsid}} {{GNF_GO|id=GO:0019031 |text = viral envelope}}
| Process = {{GNF_GO|id=GO:0006313 |text = transposition, DNA-mediated}} {{GNF_GO|id=GO:0006949 |text = syncytium formation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 30816
| Hs_Ensembl = ENSG00000197604
| Hs_RefseqProtein = NP_055405
| Hs_RefseqmRNA = NM_014590
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 91936015
| Hs_GenLoc_end = 91937631
| Hs_Uniprot = Q9UQF0
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Endogenous retroviral family W, env(C7), member 1 (syncytin)''', also known as '''ERVWE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The product of this gene, syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.<ref>{{cite web | title = Entrez Gene: ERVWE1 endogenous retroviral family W, env(C7), member 1 (syncytin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30816| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Muir A, Lever A, Moffett A |title=Expression and functions of human endogenous retroviruses in the placenta: an update. |journal=Placenta |volume=25 Suppl A |issue= |pages= S16-25 |year= 2004 |pmid= 15033302 |doi= 10.1016/j.placenta.2004.01.012 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:14:47 AM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FBXW7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ovp.
| PDB = {{PDB2|2ovp}}, {{PDB2|2ovq}}, {{PDB2|2ovr}}
| Name = F-box and WD repeat domain containing 7
| HGNCid = 16712
| Symbol = FBXW7
| AltSymbols =; AGO; CDC4; DKFZp686F23254; FBW7; FBX30; FBXW6; SEL-10; SEL10
| OMIM = 606278
| ECnumber =
| Homologene = 69520
| MGIid = 1354695
| GeneAtlas_image1 = PBB_GE_FBXW7_218751_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 55294
| Hs_Ensembl = ENSG00000109670
| Hs_RefseqProtein = NP_001013433
| Hs_RefseqmRNA = NM_001013415
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 153461860
| Hs_GenLoc_end = 153675622
| Hs_Uniprot = Q969H0
| Mm_EntrezGene = 50754
| Mm_Ensembl = ENSMUSG00000028086
| Mm_RefseqmRNA = NM_080428
| Mm_RefseqProtein = NP_536353
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 85038138
| Mm_GenLoc_end = 85063572
| Mm_Uniprot = Q8VBV4
}}
}}
'''F-box and WD repeat domain containing 7''', also known as '''FBXW7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: FBXW7 F-box and WD repeat domain containing 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55294| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 9:55:30 AM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GTF2H2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z60.
| PDB = {{PDB2|1z60}}
| Name = General transcription factor IIH, polypeptide 2, 44kDa
| HGNCid = 4656
| Symbol = GTF2H2
| AltSymbols =; BTF2; TFIIH; BTF2P44; MGC102806; T-BTF2P44
| OMIM = 601748
| ECnumber =
| Homologene = 1159
| MGIid = 1345669
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008135 |text = translation factor activity, nucleic acid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005675 |text = holo TFIIH complex}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006352 |text = transcription initiation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0009411 |text = response to UV}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2966
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001506
| Hs_RefseqmRNA = NM_001515
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 23894
| Mm_Ensembl = ENSMUSG00000021639
| Mm_RefseqmRNA = NM_022011
| Mm_RefseqProtein = NP_071294
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 101568837
| Mm_GenLoc_end = 101592836
| Mm_Uniprot = Q7TPV0
}}
}}
'''General transcription factor IIH, polypeptide 2, 44kDa''', also known as '''GTF2H2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.<ref>{{cite web | title = Entrez Gene: GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2966| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Svejstrup JQ, Vichi P, Egly JM |title=The multiple roles of transcription/repair factor TFIIH. |journal=Trends Biochem. Sci. |volume=21 |issue= 9 |pages= 346-50 |year= 1996 |pmid= 8870499 |doi= }}
*{{cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24-7 |year= 1998 |pmid= 9570510 |doi= }}
*{{cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447-9 |year= 1998 |pmid= 9651670 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 9:57:15 AM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HLA-DMA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hdm.
| PDB = {{PDB2|1hdm}}, {{PDB2|2bc4}}
| Name = Major histocompatibility complex, class II, DM alpha
| HGNCid = 4934
| Symbol = HLA-DMA
| AltSymbols =; D6S222E; DMA; HLADM; RING6
| OMIM = 142855
| ECnumber =
| Homologene = 4464
| MGIid = 95921
| GeneAtlas_image1 = PBB_GE_HLA-DMA_217478_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005765 |text = lysosomal membrane}} {{GNF_GO|id=GO:0005771 |text = multivesicular body}} {{GNF_GO|id=GO:0010008 |text = endosome membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016064 |text = immunoglobulin mediated immune response}} {{GNF_GO|id=GO:0019886 |text = antigen processing and presentation of exogenous peptide antigen via MHC class II}} {{GNF_GO|id=GO:0045059 |text = positive thymic T cell selection}} {{GNF_GO|id=GO:0045582 |text = positive regulation of T cell differentiation}} {{GNF_GO|id=GO:0050778 |text = positive regulation of immune response}} {{GNF_GO|id=GO:0051085 |text = chaperone cofactor-dependent protein folding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3108
| Hs_Ensembl = ENSG00000204257
| Hs_RefseqProtein = NP_006111
| Hs_RefseqmRNA = NM_006120
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 33024367
| Hs_GenLoc_end = 33028877
| Hs_Uniprot = P28067
| Mm_EntrezGene = 14998
| Mm_Ensembl = ENSMUSG00000037649
| Mm_RefseqmRNA = NM_010386
| Mm_RefseqProtein = NP_034516
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 33746125
| Mm_GenLoc_end = 33748991
| Mm_Uniprot = Q31096
}}
}}
'''Major histocompatibility complex, class II, DM alpha''', also known as '''HLA-DMA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.<ref>{{cite web | title = Entrez Gene: HLA-DMA major histocompatibility complex, class II, DM alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3108| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vogt AB, Kropshofer H |title=HLA-DM - an endosomal and lysosomal chaperone for the immune system. |journal=Trends Biochem. Sci. |volume=24 |issue= 4 |pages= 150-4 |year= 1999 |pmid= 10322421 |doi= }}
*{{cite journal | author=Kropshofer H, Hämmerling GJ, Vogt AB |title=The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules. |journal=Immunol. Rev. |volume=172 |issue= |pages= 267-78 |year= 2000 |pmid= 10631952 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:03:56 AM PST}
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{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NCF4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h6h.
| PDB = {{PDB2|1h6h}}, {{PDB2|1oey}}, {{PDB2|1w6x}}, {{PDB2|1w70}}, {{PDB2|1z9q}}, {{PDB2|2dyb}}
| Name = Neutrophil cytosolic factor 4, 40kDa
| HGNCid = 7662
| Symbol = NCF4
| AltSymbols =; MGC3810; NCF; P40PHOX; SH3PXD4
| OMIM = 601488
| ECnumber =
| Homologene = 525
| MGIid = 109186
| GeneAtlas_image1 = PBB_GE_NCF4_207677_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCF4_205147_x_at_tn.png
| Function = {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0043020 |text = NADPH oxidase complex}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007154 |text = cell communication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4689
| Hs_Ensembl = ENSG00000100365
| Hs_RefseqProtein = NP_000622
| Hs_RefseqmRNA = NM_000631
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 35586976
| Hs_GenLoc_end = 35604003
| Hs_Uniprot = Q15080
| Mm_EntrezGene = 17972
| Mm_Ensembl = ENSMUSG00000071715
| Mm_RefseqmRNA = NM_008677
| Mm_RefseqProtein = NP_032703
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 78072089
| Mm_GenLoc_end = 78089829
| Mm_Uniprot = Q3TBC6
}}
}}
'''Neutrophil cytosolic factor 4, 40kDa''', also known as '''NCF4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref>{{cite web | title = Entrez Gene: NCF4 neutrophil cytosolic factor 4, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4689| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Matute JD, Arias AA, Dinauer MC, Patiño PJ |title=p40phox: the last NADPH oxidase subunit. |journal=Blood Cells Mol. Dis. |volume=35 |issue= 2 |pages= 291-302 |year= 2006 |pmid= 16102984 |doi= 10.1016/j.bcmd.2005.06.010 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PAX5... {November 9, 2007 10:06:40 AM PST}
UPLOAD: Added new Image to wiki: {November 9, 2007 10:07:30 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:07:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PAX5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k78.
| PDB = {{PDB2|1k78}}, {{PDB2|1mdm}}
| Name = Paired box gene 5 (B-cell lineage specific activator)
| HGNCid = 8619
| Symbol = PAX5
| AltSymbols =; BSAP
| OMIM = 167414
| ECnumber =
| Homologene = 56419
| MGIid = 97489
| GeneAtlas_image1 = PBB_GE_PAX5_206802_at_tn.png
| GeneAtlas_image2 = PBB_GE_PAX5_221969_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5079
| Hs_Ensembl = ENSG00000196092
| Hs_RefseqProtein = NP_057953
| Hs_RefseqmRNA = NM_016734
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 36823272
| Hs_GenLoc_end = 37024476
| Hs_Uniprot = Q02548
| Mm_EntrezGene = 18507
| Mm_Ensembl = ENSMUSG00000014030
| Mm_RefseqmRNA = NM_008782
| Mm_RefseqProtein = NP_032808
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 44552606
| Mm_GenLoc_end = 44731762
| Mm_Uniprot = Q02650
}}
}}
'''Paired box gene 5 (B-cell lineage specific activator)''', also known as '''PAX5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. The PAX5 gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters, suggesting that the deregulation of PAX5 gene transcription contributes to the pathogenesis of these lymphomas. A transcript variant arising as a consequence of alternative promoter usage, and containing a different coding exon 1(B), has been described, however, its full-length nature is not known.<ref>{{cite web | title = Entrez Gene: PAX5 paired box gene 5 (B-cell lineage specific activator)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5079| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hagman J, Wheat W, Fitzsimmons D, ''et al.'' |title=Pax-5/BSAP: regulator of specific gene expression and differentiation in B lymphocytes. |journal=Curr. Top. Microbiol. Immunol. |volume=245 |issue= 1 |pages= 169-94 |year= 1999 |pmid= 10533313 |doi= }}
*{{cite journal | author=Calame KL, Lin KI, Tunyaplin C |title=Regulatory mechanisms that determine the development and function of plasma cells. |journal=Annu. Rev. Immunol. |volume=21 |issue= |pages= 205-30 |year= 2003 |pmid= 12524387 |doi= 10.1146/annurev.immunol.21.120601.141138 }}
*{{cite journal | author=Carotta S, Holmes ML, Pridans C, Nutt SL |title=Pax5 maintains cellular identity by repressing gene expression throughout B cell differentiation. |journal=Cell Cycle |volume=5 |issue= 21 |pages= 2452-6 |year= 2007 |pmid= 17102626 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:06:40 AM PST}
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{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRDX1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qq2.
| PDB = {{PDB2|1qq2}}
| Name = Peroxiredoxin 1
| HGNCid = 9352
| Symbol = PRDX1
| AltSymbols =; MSP23; NKEFA; PAG; PAGA; PAGB; TDPX2
| OMIM = 176763
| ECnumber =
| Homologene = 21685
| MGIid = 99523
| GeneAtlas_image1 = PBB_GE_PRDX1_208680_at_tn.png
| Function = {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0051920 |text = peroxiredoxin activity}}
| Component =
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5052
| Hs_Ensembl = ENSG00000117450
| Hs_RefseqProtein = NP_002565
| Hs_RefseqmRNA = NM_002574
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 45749295
| Hs_GenLoc_end = 45760215
| Hs_Uniprot = Q06830
| Mm_EntrezGene = 18477
| Mm_Ensembl = ENSMUSG00000028691
| Mm_RefseqmRNA = NM_011034
| Mm_RefseqProtein = NP_035164
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 116183531
| Mm_GenLoc_end = 116197932
| Mm_Uniprot = Q3U9J9
}}
}}
'''Peroxiredoxin 1''', also known as '''PRDX1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.<ref>{{cite web | title = Entrez Gene: PRDX1 peroxiredoxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5052| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wood ZA, Schröder E, Robin Harris J, Poole LB |title=Structure, mechanism and regulation of peroxiredoxins. |journal=Trends Biochem. Sci. |volume=28 |issue= 1 |pages= 32-40 |year= 2003 |pmid= 12517450 |doi= }}
}}
{{refend}}
{{protein-stub}}