INFO: Beginning work on CREM... {November 7, 2007 6:41:30 PM PST}
UPLOAD: Added new Image to wiki: {November 7, 2007 6:43:14 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:43:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CREM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dh3.
| PDB = {{PDB2|1dh3}}
| Name = CAMP responsive element modulator
| HGNCid = 2352
| Symbol = CREM
| AltSymbols =; ICER; MGC111110; MGC17881; MGC41893; hCREM-2
| OMIM = 123812
| ECnumber =
| Homologene = 84591
| MGIid =
| GeneAtlas_image1 = PBB_GE_CREM_207630_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CREM_209967_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CREM_210171_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008140 |text = cAMP response element binding protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1390
| Hs_Ensembl = ENSG00000095794
| Hs_RefseqProtein = NP_001872
| Hs_RefseqmRNA = NM_001881
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 35455807
| Hs_GenLoc_end = 35541892
| Hs_Uniprot = Q03060
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CAMP responsive element modulator''', also known as '''CREM''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.<ref>{{cite web | title = Entrez Gene: CREM cAMP responsive element modulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1390| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Don J, Stelzer G |title=The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 115-24 |year= 2003 |pmid= 11988318 |doi= }}
*{{cite journal | author=Yan C, Miller CL, Abe J |title=Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. |journal=Circ. Res. |volume=100 |issue= 4 |pages= 489-501 |year= 2007 |pmid= 17332439 |doi= 10.1161/01.RES.0000258451.44949.d7 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on F12... {November 7, 2007 6:44:51 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:45:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coagulation factor XII (Hageman factor)
| HGNCid = 3530
| Symbol = F12
| AltSymbols =; HAF
| OMIM = 234000
| ECnumber =
| Homologene = 425
| MGIid = 1891012
| GeneAtlas_image1 = PBB_GE_F12_205774_at_tn.png
| Function = {{GNF_GO|id=GO:0003805 |text = coagulation factor XIa activity}} {{GNF_GO|id=GO:0003806 |text = coagulation factor XIIa activity}} {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0042730 |text = fibrinolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2161
| Hs_Ensembl = ENSG00000131187
| Hs_RefseqProtein = NP_000496
| Hs_RefseqmRNA = NM_000505
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 176761747
| Hs_GenLoc_end = 176769183
| Hs_Uniprot = P00748
| Mm_EntrezGene = 58992
| Mm_Ensembl = ENSMUSG00000021492
| Mm_RefseqmRNA = NM_021489
| Mm_RefseqProtein = NP_067464
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 55427588
| Mm_GenLoc_end = 55436415
| Mm_Uniprot =
}}
}}
'''Coagulation factor XII (Hageman factor)''', also known as '''F12''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.<ref>{{cite web | title = Entrez Gene: F12 coagulation factor XII (Hageman factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2161| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Girolami A, Randi ML, Gavasso S, ''et al.'' |title=The occasional venous thromboses seen in patients with severe (homozygous) FXII deficiency are probably due to associated risk factors: a study of prevalence in 21 patients and review of the literature. |journal=J. Thromb. Thrombolysis |volume=17 |issue= 2 |pages= 139-43 |year= 2005 |pmid= 15306750 |doi= 10.1023/B:THRO.0000037670.42776.cd }}
*{{cite journal | author=Renné T, Gailani D |title=Role of Factor XII in hemostasis and thrombosis: clinical implications. |journal=Expert review of cardiovascular therapy |volume=5 |issue= 4 |pages= 733-41 |year= 2007 |pmid= 17605651 |doi= 10.1586/14779072.5.4.733 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on HLA-F... {November 7, 2007 6:46:15 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:47:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Major histocompatibility complex, class I, F
| HGNCid = 4963
| Symbol = HLA-F
| AltSymbols =; HLA-5.4; HLA-CDA12; HLAF
| OMIM = 143110
| ECnumber =
| Homologene = 85957
| MGIid = 95931
| GeneAtlas_image1 = PBB_GE_HLA-F_204806_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_HLA-F_221875_x_at_tn.png
| Function = {{GNF_GO|id=GO:0032393 |text = MHC class I receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
| Process = {{GNF_GO|id=GO:0002474 |text = antigen processing and presentation of peptide antigen via MHC class I}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3134
| Hs_Ensembl = ENSG00000137403
| Hs_RefseqProtein = NP_061823
| Hs_RefseqmRNA = NM_018950
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 29832424
| Hs_GenLoc_end = 29836307
| Hs_Uniprot = P30511
| Mm_EntrezGene = 15013
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_010392
| Mm_RefseqProtein = NP_034522
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Major histocompatibility complex, class I, F''', also known as '''HLA-F''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-F belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-F binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 42 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. The HLA-F gene exhibits few polymorphisms.<ref>{{cite web | title = Entrez Gene: HLA-F major histocompatibility complex, class I, F| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3134| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580-5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141 }}
*{{cite journal | author=Greenway AL, Holloway G, McPhee DA, ''et al.'' |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323-35 |year= 2004 |pmid= 12734410 |doi= }}
*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}
*{{cite journal | author=Leavitt SA, SchOn A, Klein JC, ''et al.'' |title=Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm. |journal=Curr. Protein Pept. Sci. |volume=5 |issue= 1 |pages= 1-8 |year= 2004 |pmid= 14965316 |doi= }}
*{{cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, ''et al.'' |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141-51 |year= 2004 |pmid= 15078178 |doi= }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 16091223 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on LAMA5... {November 7, 2007 6:50:09 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:50:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Laminin, alpha 5
| HGNCid = 6485
| Symbol = LAMA5
| AltSymbols =; KIAA1907
| OMIM = 601033
| ECnumber =
| Homologene = 4060
| MGIid = 105382
| GeneAtlas_image1 = PBB_GE_LAMA5_210150_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005605 |text = basal lamina}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0045995 |text = regulation of embryonic development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3911
| Hs_Ensembl = ENSG00000130702
| Hs_RefseqProtein = NP_005551
| Hs_RefseqmRNA = NM_005560
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 60317510
| Hs_GenLoc_end = 60375763
| Hs_Uniprot = O15230
| Mm_EntrezGene = 16776
| Mm_Ensembl = ENSMUSG00000015647
| Mm_RefseqmRNA = XM_203796
| Mm_RefseqProtein = XP_203796
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 180105782
| Mm_GenLoc_end = 180155210
| Mm_Uniprot = Q3TZ05
}}
}}
'''Laminin, alpha 5''', also known as '''LAMA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.<ref>{{cite web | title = Entrez Gene: LAMA5 laminin, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3911| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
{November 7, 2007 6:43:14 PM PST} 
{November 7, 2007 6:57:25 PM PST} 
