- INFO: Beginning work on ACY1... {January 5, 2008 2:15:17 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACY1 image.jpg {January 5, 2008 2:15:51 PM PST}
- REDIRECT: Protein Redirected to: ACY1 {January 5, 2008 2:15:58 PM PST}
- CREATED: Created new protein page: ACY1 {January 5, 2008 2:16:07 PM PST}
- INFO: Beginning work on AKAP6... {January 5, 2008 2:26:45 PM PST}
- REDIRECT: Protein Redirected to: AKAP6 {January 5, 2008 2:26:59 PM PST}
- CREATED: Created new protein page: AKAP6 {January 5, 2008 2:27:07 PM PST}
- INFO: Beginning work on APBA3... {January 5, 2008 2:30:49 PM PST}
- REDIRECT: Protein Redirected to: APBA3 {January 5, 2008 2:31:43 PM PST}
- CREATED: Created new protein page: APBA3 {January 5, 2008 2:31:54 PM PST}
- INFO: Beginning work on CDY1... {January 5, 2008 2:17:15 PM PST}
- REDIRECT: Protein Redirected to: CDY1 {January 5, 2008 2:17:29 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {January 5, 2008 2:17:31 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {January 5, 2008 2:17:31 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {January 5, 2008 2:17:31 PM PST}
- UPDATED: Updated protein page: CDY1 {January 5, 2008 2:17:36 PM PST}
- INFO: Beginning work on CGB... {January 5, 2008 2:16:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {January 5, 2008 2:16:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_summary = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CGB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hcn.
| PDB = {{PDB2|1hcn}}, {{PDB2|1hrp}}, {{PDB2|1qfw}}
| Name = Chorionic gonadotropin, beta polypeptide
| HGNCid = 1886
| Symbol = CGB
| AltSymbols =; CGB3; hCGB; HCG; MGC119822
| OMIM = 118860
| ECnumber =
| Homologene = 37338
| MGIid =
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1082
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000728
| Hs_RefseqmRNA = NM_000737
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chorionic gonadotropin, beta polypeptide''', also known as '''CGB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CGB chorionic gonadotropin, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1082| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.<ref name="entrez">{{cite web | title = Entrez Gene: CGB chorionic gonadotropin, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1082| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*cite journal | author=Bo M, Boime I |title=Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3179-84 |year= 1992 |pmid= 1371113 |doi=
*cite journal | author=Maruo T, Ladines-Llave CA, Matsuo H, ''et al.'' |title=A novel change in cytologic localization of human chorionic gonadotropin and human placental lactogen in first-trimester placenta in the course of gestation. |journal=Am. J. Obstet. Gynecol. |volume=167 |issue= 1 |pages= 217-22 |year= 1992 |pmid= 1442929 |doi=
*cite journal | author=Rothman PA, Chao VA, Taylor MR, ''et al.'' |title=Extraplacental human fetal tissues express mRNA transcripts encoding the human chorionic gonadotropin-beta subunit protein. |journal=Mol. Reprod. Dev. |volume=33 |issue= 1 |pages= 1-6 |year= 1992 |pmid= 1510839 |doi= 10.1002/mrd.1080330102
*{{cite journal | author=Weisshaar G, Hiyama J, Renwick AG |title=Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. |journal=Glycobiology |volume=1 |issue= 4 |pages= 393-404 |year= 1992 |pmid= 1820200 |doi= }}
*cite journal | author=Xie YB, Wang H, Segaloff DL |title=Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. |journal=J. Biol. Chem. |volume=265 |issue= 35 |pages= 21411-4 |year= 1991 |pmid= 2254302 |doi=
*{{cite journal | author=Policastro PF, Daniels-McQueen S, Carle G, Boime I |title=A map of the hCG beta-LH beta gene cluster. |journal=J. Biol. Chem. |volume=261 |issue= 13 |pages= 5907-16 |year= 1986 |pmid= 2422163 |doi= }}
*cite journal | author=Jameson JL, Lindell CM, Habener JF |title=Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. |journal=DNA |volume=5 |issue= 3 |pages= 227-34 |year= 1986 |pmid= 2424697 |doi=
*cite journal | author=Morrish DW, Marusyk H, Bhardwaj D |title=Ultrastructural localization of human placental lactogen in distinctive granules in human term placenta: comparison with granules containing human chorionic gonadotropin. |journal=J. Histochem. Cytochem. |volume=36 |issue= 2 |pages= 193-7 |year= 1988 |pmid= 2447154 |doi=
*{{cite journal | author=Otani T, Otani F, Krych M, ''et al.'' |title=Identification of a promoter region in the CG beta gene cluster. |journal=J. Biol. Chem. |volume=263 |issue= 15 |pages= 7322-9 |year= 1988 |pmid= 2452822 |doi= }}
*cite journal | author=Jameson JL, Lindell CM |title=Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP. |journal=Mol. Cell. Biol. |volume=8 |issue= 12 |pages= 5100-7 |year= 1989 |pmid= 2468994 |doi=
*cite journal | author=Matzuk MM, Keene JL, Boime I |title=Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction. |journal=J. Biol. Chem. |volume=264 |issue= 5 |pages= 2409-14 |year= 1989 |pmid= 2536708 |doi=
*cite journal | author=Jameson JL, Lindell CM, Habener JF |title=Gonadotropin and thyrotropin alpha- and beta-subunit gene expression in normal and neoplastic tissues characterized using specific messenger ribonucleic acid hybridization probes. |journal=J. Clin. Endocrinol. Metab. |volume=64 |issue= 2 |pages= 319-27 |year= 1987 |pmid= 3098775 |doi=
*{{cite journal | author=Gaspard UJ, Hustin J, Reuter AM, ''et al.'' |title=Immunofluorescent localization of placental lactogen, chorionic gonadotrophin and its alpha and beta subunits in organ cultures of human placenta. |journal=Placenta |volume=1 |issue= 2 |pages= 135-44 |year= 1981 |pmid= 6160572 |doi= }}
*cite journal | author=Policastro P, Ovitt CE, Hoshina M, ''et al.'' |title=The beta subunit of human chorionic gonadotropin is encoded by multiple genes. |journal=J. Biol. Chem. |volume=258 |issue= 19 |pages= 11492-9 |year= 1983 |pmid= 6194155 |doi=
*cite journal | author=Keutmann HT, Ratanabanangkoon K, Pierce MW, ''et al.'' |title=Phosphorylation of human choriogonadotropin. Stoichiometry and sites of phosphate incorporation. |journal=J. Biol. Chem. |volume=258 |issue= 23 |pages= 14521-6 |year= 1984 |pmid= 6196363 |doi=
*cite journal | author=Julier C, Weil D, Couillin P, ''et al.'' |title=The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19. |journal=Hum. Genet. |volume=67 |issue= 2 |pages= 174-7 |year= 1984 |pmid= 6204923 |doi=
*cite journal | author=Talmadge K, Boorstein WR, Fiddes JC |title=The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone. |journal=DNA |volume=2 |issue= 4 |pages= 281-9 |year= 1984 |pmid= 6319099 |doi=
*cite journal | author=Talmadge K, Vamvakopoulos NC, Fiddes JC |title=Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. |journal=Nature |volume=307 |issue= 5946 |pages= 37-40 |year= 1984 |pmid= 6690982 |doi=
*cite journal | author=Fiddes JC, Goodman HM |title=The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. |journal=Nature |volume=286 |issue= 5774 |pages= 684-7 |year= 1980 |pmid= 6774259 |doi=
*cite journal | author=McGregor WG, Raymoure WJ, Kuhn RW, Jaffe RB |title=Fetal tissue can synthesize a placental hormone. Evidence for chorionic gonadotropin beta-subunit synthesis by human fetal kidney. |journal=J. Clin. Invest. |volume=68 |issue= 1 |pages= 306-9 |year= 1981 |pmid= 7251865 |doi=
}}
{{refend}}
{{protein-stub}}
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end log.
