Abortive initiation edit
Recent Science article finds in vivo production of prokaryotic abortive RNA transcripts. Says euks have abortive initiation, but refs don't support[1]. But this article on promoter clearance does support it. I'm wrong. [2]
CPDs edit
UVB produces TTs, followed by CTs, least CCs. UVA produces greater preponderance of TTs. See fig 2 [3]
Actually CC and CTs result in more mutations, because of the A rule [4]
See also [5]
PMC359977
See also edit
Race and Genetics edit
First, there's a Race and genetics article. There's also one on Human genetic variation, and then Lewontin's fallacy is worth a look. Witherspoon has a good review of genetic variation, and explains how most variation can be within populations, but it's still possible to classify people fairly accurately into groups with multiple loci[6].
Refs edit
- ^ Goldman, S.; Ebright, R.; Nickels, B. (May 2009). "Direct detection of abortive RNA transcripts in vivo". Science. 324 (5929): 927–928. doi:10.1126/science.1169237. PMC 2718712. PMID 19443781.
- ^ Dvir, A. (Sep 2002). "Promoter escape by RNA polymerase II". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1577 (2): 208–223. doi:10.1016/s0167-4781(02)00453-0. ISSN 0006-3002. PMID 12213653.
- ^ Mouret, S; Baudouin, C; Charveron, M; Favier, A; Cadet, J; Douki, T (Sep 2006). "Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation". Proceedings of the National Academy of Sciences of the United States of America. 103 (37): 13765–70. doi:10.1073/pnas.0604213103. ISSN 0027-8424. PMC 1564232. PMID 16954188.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ Brash DE, Rudolph JA, Simon JA; et al. (November 1991). "A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10124–8. doi:10.1073/pnas.88.22.10124. PMC 52880. PMID 1946433.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ Rochette, P. J. (2003). "UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells". Nucleic Acids Research. 31 (11): 2786–2794. doi:10.1093/nar/gkg402. PMC 156735. PMID 12771205.
- ^ Witherspoon DJ, Wooding S, Rogers AR; et al. (May 2007). "Genetic similarities within and between human populations". Genetics. 176 (1): 351–9. doi:10.1534/genetics.106.067355. PMC 1893020. PMID 17339205.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)