Talk:RNA therapeutics

Individuals with a conflict of interest, particularly those representing the subject of the article, are strongly advised not to directly edit the article. See Wikipedia:Conflict of interest. You may request corrections or suggest content here on the Talk page for independent editors to review, or contact us if the issue is urgent.

This is the talk page for discussing improvements to the RNA therapeutics article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: 1: 365 days

This article was the subject of an educational assignment. Further details are available on the course page.

The Wikimedia Foundation's Terms of Use require that editors disclose their "employer, client, and affiliation" with respect to any paid contribution; see WP:PAID. For advice about reviewing paid contributions, see WP:COIRESPONSE.

J at BioNTech (talk · contribs) has been paid by BioNTech on their behalf. (Disclosure)

Molecular Biology: Genetics / MCB

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Genetics task force (assessed as Low-importance).
	This article is supported by the Molecular and Cell Biology task force.

Medicine Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.

Viruses Low‑importance

	Viruses portal This article is within the scope of WikiProject Viruses, a collaborative effort to improve the coverage of viruses on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.VirusesWikipedia:WikiProject VirusesTemplate:WikiProject Virusesvirus articles
Low	This article has been rated as Low-importance on the project's importance scale.

Veterinary medicine Low‑importance

	This article is within the scope of WikiProject Veterinary medicine, a collaborative effort to improve the coverage of Veterinary medicine on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Veterinary medicineWikipedia:WikiProject Veterinary medicineTemplate:WikiProject Veterinary medicineVeterinary medicine articles
Low	This article has been rated as Low-importance on the project's importance scale.

Pharmacology Low‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
Low	This article has been rated as Low-importance on the project's importance scale.

Microbiology Low‑importance

	This article is within the scope of WikiProject Microbiology, a collaborative effort to improve the coverage of Microbiology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.MicrobiologyWikipedia:WikiProject MicrobiologyTemplate:WikiProject MicrobiologyMicrobiology articles
Low	This article has been rated as Low-importance on the project's importance scale.

.

RNA therapeutics Peer Review

First of all, nice work! I think the article is of good organization and very clear! Yet there are only a few points I am a little bit confused about.

In the siRNA part, is it a typo in the first sentence "siRNA are short. double stranded pieces of RNA "? I guess you mean short and double-stranded. Also, the sentences in this paragraph seem to end in double ".". In addition, I am wondering if it is necessary to cite the same paper in every sentence in this paragraph. It should be fine to cite at the end of this paragraph.

Again in siRNA part, it is mentioned that several diseases can be treated with siRNA. Would you list some examples? This paragraph emphasizes the problems in drug delivery but the target of siRNA is not indicated. Is that RNA/DNA/protein? Or more specifically, which protein it is? I believe writing about this will help people understand this paragraph! Also, it will be very interesting if you could introduce the mechanism of which siRNA cure the disease.

In the miRNA part, I personally suggest it is better to introduce the full name "microRNA" at least once, so that it is easier for the public audience to understand.

Thank you! Please let me know how you think!

YihuaL (talk)

RNA Therapeutics Peer Review 1

Great work so far. The page has a logical order and is clearly written! Below are some remarks to further elevate the page:

It might be more useful to the reader to describe RNA as something other than the second product of the Central Dogma. The Central Dogma is really just a schematic and so perhaps writing what RNA stands for or what it's biological significance is without referring to the Central Dogma model would fare better. You can of course elaborate on the Central Dogma model later, however for an introduction it would have more impact and get straight to the point by describing RNA for what it is without referring to the Central Dogma theory. Also, the first sentence uses "and" a lot. It would be good to word the first part in a concise and clear way while placing emphasis on the key points. Eliminating "and" would help do this. This would apply to the second sentence as well which is a little difficult to read and decipher. Overall, the last sentence is clear and points the reader to more information.

I don't think you need to link RNA every time it is used (or any other terms as well). It might be distracting. Also under mRNA, you could elaborate on why mRNA "is translated instantly". I also don't think having a metaphor to drug factories aligns with the overall professional tone of wiki pages. Lastly, this section would benefit from having one main point per paragraph. I think you all did a nice job in providing current research efforts to develop mRNA therapeutics.

For the antisense RNA, you could also separate the paragraphs by points you want to emphasize. Also, it would be nice to have the sentences written straightforwardly.

For RNAi you could discuss if/why there is limited research on their therapeutic effects.

Perhaps, you could include the size of each of these RNAs in the first sentence.

Nice work.

Hoorayforrna (talk)Hoorayforrna (talk)

Add topic