RNA 3'-terminal phosphate cyclase-like protein is an enzyme that in humans is encoded by the RCL1 gene.[5]
Copy number variants to the RCL1 gene are associated with a range of neuropsychiatric phenotypes,[6] and a missense variant associated with depression.[7]
See also edit
References edit
- ^ a b c GRCh38: Ensembl release 89: ENSG00000120158 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024785 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: RCL1 RNA terminal phosphate cyclase-like 1".
- ^ Brownstein CA, Smith RS, Rodan LH, et al. (May 2021). "RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes". Molecular Psychiatry. 26 (5): 1706–1718. doi:10.1038/s41380-021-01035-y. PMC 8159744. PMID 33597717.
- ^ Amin N, de Vrij FM, Baghdadi M, et al. (May 2018). "A rare missense variant in RCL1 segregates with depression in extended families". Molecular Psychiatry. 23 (5): 1120–1126. doi:10.1038/mp.2017.49. PMC 5984098. PMID 28322274.
Further reading edit
- Kimura K, Wakamatsu A, Suzuki Y, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Andersen JS, Lam YW, Leung AK, et al. (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Andersen JS, Lyon CE, Fox AH, et al. (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Zhang QH, Ye M, Wu XY, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Billy E, Wegierski T, Nasr F, et al. (May 2000). "Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis". The EMBO Journal. 19 (9): 2115–26. doi:10.1093/emboj/19.9.2115. PMC 305690. PMID 10790377.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Genschik P, Billy E, Swianiewicz M, et al. (May 1997). "The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea". The EMBO Journal. 16 (10): 2955–67. doi:10.1093/emboj/16.10.2955. PMC 1169903. PMID 9184239.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Vicente O, Filipowicz W (September 1988). "Purification of RNA 3'-terminal phosphate cyclase from HeLa cells. Covalent modification of the enzyme with different nucleotides". European Journal of Biochemistry. 176 (2): 431–9. doi:10.1111/j.1432-1033.1988.tb14300.x. PMID 3416880.
External links edit
- RCL1 human gene location in the UCSC Genome Browser.
- RCL1 human gene details in the UCSC Genome Browser.
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