MK8 may refer to:
- Mario Kart 8, a 2014 Wii U kart racing video game in the Mario Kart series
- Kallikrein 8, an enzyme
- Mitsubishi Kinsei (also MK8), a 14-cylinder, air-cooled, twin-row radial aircraft engine
- Volkswagen Golf Mk8, the eighth generation of the Volkswagen Golf vehicle
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