Kallikrein 8 (EC 3.4.21.118, KLK8, PRSS19, human kallikrein 8, hK8, mK8, ovasin, tumor-associated differentially expressed gene 14, TADG-14, NP, neuropsin) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Kallikrein 8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.118 | ||||||||
| CAS no. | 171715-15-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
The enzyme is activated by removal of an N-terminal prepropeptide.
References
edit- ^ Chen ZL, Yoshida S, Kato K, Momota Y, Suzuki J, Tanaka T, Ito J, Nishino H, Aimoto S, Kiyama H (July 1995). "Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus". The Journal of Neuroscience. 15 (7 Pt 2): 5088–97. doi:10.1523/JNEUROSCI.15-07-05088.1995. PMC 6577896. PMID 7623137.
- ^ Shimizu C, Yoshida S, Shibata M, Kato K, Momota Y, Matsumoto K, Shiosaka T, Midorikawa R, Kamachi T, Kawabe A, Shiosaka S (May 1998). "Characterization of recombinant and brain neuropsin, a plasticity-related serine protease". The Journal of Biological Chemistry. 273 (18): 11189–96. doi:10.1074/jbc.273.18.11189. PMID 9556608.
- ^ Rajapakse S, Ogiwara K, Takano N, Moriyama A, Takahashi T (December 2005). "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins". FEBS Letters. 579 (30): 6879–84. doi:10.1016/j.febslet.2005.11.039. hdl:2115/985. PMID 16337200.
- ^ Kishi T, Cloutier SM, Kündig C, Deperthes D, Diamandis EP (June 2006). "Activation and enzymatic characterization of recombinant human kallikrein 8" (PDF). Biological Chemistry. 387 (6): 723–31. doi:10.1515/BC.2006.091. PMID 16800733.
External links
edit- Kallikrein+8 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
