This is a list of opioids, opioid antagonists and inverse agonists.

Opium poppy (Papaver somniferum) flower

Opium and poppy straw derivatives

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Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

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Natural opiates

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Opium alkaloids

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Alkaloid salts mixtures

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Semisynthetics including Bentley compounds

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Morphine family

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3,6-diesters of morphine

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Codeine-dionine family

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Morphinones and morphols

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Morphides

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Dihydrocodeine series

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Nitrogen morphine derivatives

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Hydrazones

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Structures
Hydrazones
  Oxymorphazone

Halogenated morphine derivatives

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Structures

Active opiate metabolites

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Morphinans

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Levomethorphan

Morphinan series

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Others

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Benzomorphans

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4-Phenylpiperidines

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Pethidine

Pethidines (meperidines)

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Prodines

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Ketobemidones

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Others

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Structures
Other phenylpiperidines
 Alvimopan   Loperamide   LS-115509   Picenadol

Open chain opioids

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Methadone

Amidones

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Methadols

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Moramides

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Thiambutenes

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Phenalkoxams

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Ampromides

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Structures

Others

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Structures
Other open chain opioids
 

Embutramide

 

IC-26

 

Isoaminile

 

Lefetamine

 

R-4066

Anilidopiperidines

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Fentanyl

Oripavine derivatives

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Thienorphine

Phenazepanes

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Pirinitramides

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Structures
Pirinitramides
 

Bezitramide

 

Piritramide

Benzimidazoles

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Indoles

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Beta-Amino Ketones

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Diphenylmethylpiperazines

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Structures
Diphenylmethylpiperazines
 

BW373U86

 

DPI-221

 

DPI-287

 

DPI-3290

 

SNC-80

Opioid peptides

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β-neoendorphin

Dynorphins

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Structures

Endomorphins

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Endorphins

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Enkephalins

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Propeptides

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Others / unknown

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Others

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Opioid antagonists and inverse agonists

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Biased ligands

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Receptor heteromer targeting ligands

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Uncategorized opioids

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Combination drug formulations containing opioids

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See also

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References

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  1. ^ ChemIndex CAS Registry Number 3371-56-0
  2. ^ ChemIndex CAS Registry Number 509-56-8
  3. ^ ChemIndex CAS Registry Number 63715-94-6
  4. ^ NCBI PubChem SID 750205
  5. ^ chembase [permanent dead link] cbid_346222
  6. ^ Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
  7. ^ Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.
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  • Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740