Zappalà or Zappala is a surname. Notable people with the surname include:

  • Frank J. Zappala (1898–1988), American politician and lawyer
  • Gregorio Zappalà (1833–1908), Italian sculptor
  • Stefano Zappalà (1941–2018), Italian politician and Member of the European Parliament for Central with the Forza Italia
  • Stephen Zappala, American Democratic politician and attorney who is the District Attorney of Allegheny County, Pennsylvania
  • Stephen Zappala Sr. (1932–2021), American lawyer and former Pennsylvania Supreme Court Chief Justice
  • Vincenzo Zappalà (born 1945), Italian astronomer

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