ZHX2

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.

ZHX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMP, 3NAU
Identifiers
Aliases	ZHX2, AFR1, RAF, zinc fingers and homeoboxes 2
External IDs	OMIM: 609185 MGI: 2683087 HomoloGene: 8968 GeneCards: ZHX2
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.13 Start 122,781,655 bp End 122,974,510 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 D1|15 24.01 cM Start 57,558,061 bp End 57,703,228 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery saphenous vein inferior olivary nucleus internal globus pallidus right ventricle caput epididymis lactiferous duct germinal epithelium urethra optic nerve Top expressed in knee joint triceps brachii muscle vastus lateralis muscle otolith organ temporal muscle utricle skeletal muscle tissue sternocleidomastoid muscle ankle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein homodimerization activity transcription corepressor activity metal ion binding identical protein binding protein heterodimerization activity nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol plasma membrane Biological process regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II mRNA catabolic process negative regulation of neuron differentiation somatic stem cell population maintenance transcription, DNA-templated retinal bipolar neuron differentiation nervous system development cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22882 387609 Ensembl ENSG00000178764 ENSMUSG00000071757 UniProt Q9Y6X8 Q8C0C0 RefSeq (mRNA) NM_014943 NM_001362797 NM_199449 RefSeq (protein) NP_055758 NP_001349726 NP_955520 Location (UCSC) Chr 8: 122.78 – 122.97 Mb Chr 15: 57.56 – 57.7 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.

See also

• Chromosome 8 (human)
• NFYA
• Protein dimer

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3". Gene. 323: 133–40. doi:10.1016/j.gene.2003.09.013. PMID 14659886.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• de Andrade TG, Peterson KR, Cunha AF, et al. (2006). "Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster". Blood Cells Mol. Dis. 37 (2): 82–90. doi:10.1016/j.bcmd.2006.07.003. PMID 16952470.
• Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
• Hu S, Zhang M, Lv Z, et al. (2007). "Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis". Neoplasma. 54 (3): 207–11. PMID 17447851.