ZHX1

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.

ZHX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ECB, 2GHF, 2LY9, 3NAR
Identifiers
Aliases	ZHX1, zinc fingers and homeoboxes 1
External IDs	OMIM: 604764 MGI: 109271 HomoloGene: 5225 GeneCards: ZHX1
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.13 Start 123,248,451 bp End 123,275,541 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D1 Start 57,910,399 bp End 57,939,937 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon lactiferous duct cerebellar vermis internal globus pallidus medulla oblongata superior vestibular nucleus human penis external globus pallidus corpus callosum Top expressed in spermatocyte white adipose tissue uterus hippocampus proper ovary quadriceps femoris muscle muscle tissue skeletal muscle tissue liver lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding transcription corepressor activity metal ion binding protein heterodimerization activity nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11244 22770 Ensembl ENSG00000165156 ENSMUSG00000022361 UniProt Q9UKY1 P70121 RefSeq (mRNA) NM_001017926 NM_007222 NM_001042438 NM_009572 RefSeq (protein) NP_001017926 NP_009153 NP_001035903 NP_033598 Location (UCSC) Chr 8: 123.25 – 123.28 Mb Chr 15: 57.91 – 57.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.

Interactions

ZHX1 has been shown to interact with NFYA.

Further reading

• Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA". FEBS Letters. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058. S2CID 28576187.
• Hirano S, Yamada K, Kawata H, Shou Z, Mizutani T, Yazawa T, et al. (May 2002). "Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer". Gene. 290 (1–2): 107–14. doi:10.1016/S0378-1119(02)00553-X. PMID 12062805.
• Yamada K, Kawata H, Matsuura K, Shou Z, Hirano S, Mizutani T, et al. (September 2002). "Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1)". Biochemical and Biophysical Research Communications. 297 (2): 368–74. doi:10.1016/S0006-291X(02)02203-9. PMID 12237128.
• Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, et al. (July 2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". The Biochemical Journal. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
• Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, et al. (August 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". The Biochemical Journal. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, et al. (September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Liu G, Clement LC, Kanwar YS, Avila-Casado C, Chugh SS (December 2006). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". The Journal of Biological Chemistry. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
• Kim SH, Park J, Choi MC, Kim HP, Park JH, Jung Y, et al. (April 2007). "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression". Biochemical and Biophysical Research Communications. 355 (2): 318–23. doi:10.1016/j.bbrc.2007.01.187. PMID 17303076.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9UKY1 (Zinc fingers and homeoboxes protein 1) at the PDBe-KB.