ZFYVE20

Rabenosyn-5 is a protein that in humans is encoded by the ZFYVE20 gene.

RBSN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YZM, 1Z0J, 1Z0K
Identifiers
Aliases	RBSN, Rabenosyn-5, ZFYVE20, rabenosyn, RAB effector
External IDs	OMIM: 609511 MGI: 1925537 HomoloGene: 41477 GeneCards: RBSN
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.1 Start 15,070,073 bp End 15,099,163 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 92,163,693 bp End 92,191,906 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell tibialis anterior muscle cerebellar vermis Brodmann area 23 Brodmann area 46 middle temporal gyrus internal globus pallidus corpus callosum postcentral gyrus entorhinal cortex Top expressed in supraoptic nucleus hand otolith organ utricle medullary collecting duct ascending aorta superior cervical ganglion anterior horn of spinal cord ventral tegmental area paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding protein binding nucleic acid binding Cellular component endosome early endosome membrane intracellular membrane-bounded organelle membrane cytoplasmic side of endosome membrane plasma membrane endosome membrane extracellular exosome cytosol Biological process endosomal vesicle fusion endocytosis vacuole inheritance Golgi to endosome transport blood coagulation endosomal transport protein transport regulation of Golgi organization Golgi to lysosome transport early endosome to Golgi transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64145 78287 Ensembl ENSG00000131381 ENSMUSG00000014550 UniProt Q9H1K0 Q80Y56 RefSeq (mRNA) NM_001302378 NM_022340 NM_030081 RefSeq (protein) NP_001289307 NP_071735 NP_084357 Location (UCSC) Chr 3: 15.07 – 15.1 Mb Chr 6: 92.16 – 92.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ZFYVE20 has been shown to interact with RAB5A.

Further reading

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Eathiraj S, Pan X, Ritacco C, Lambright DG (2005). "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5". Nature. 436 (7049): 415–9. Bibcode:2005Natur.436..415E. doi:10.1038/nature03798. PMC 1360218. PMID 16034420.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Naslavsky N, Boehm M, Backlund PS, Caplan S (2005). "Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane". Mol. Biol. Cell. 15 (5): 2410–22. doi:10.1091/mbc.E03-10-0733. PMC 404033. PMID 15020713.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• de Renzis S, Sönnichsen B, Zerial M (2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nat. Cell Biol. 4 (2): 124–33. doi:10.1038/ncb744. PMID 11788822. S2CID 6596498.