Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.[5][6][7]

ZC3HAV1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZC3HAV1, ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, zinc finger CCCH-type containing, antiviral 1
External IDsOMIM: 607312; MGI: 1926031; HomoloGene: 10585; GeneCards: ZC3HAV1; OMA:ZC3HAV1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020119
NM_024625
NM_001363491

NM_028421
NM_028864
NM_001347122

RefSeq (protein)

NP_064504
NP_078901
NP_001350420

NP_001334051
NP_082697
NP_083140

Location (UCSC)Chr 7: 139.04 – 139.13 MbChr 6: 38.28 – 38.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and at least four isoform variants have been described.[8][7]

Mechanism of zinc-finger antiviral protein (ZAP) recognition of specific target RNA, and the process by which ZAP coordinates downstream RNA degradation (right). ZAP-RNA complex protein ribbon diagram (left).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105939Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029826Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gao G, Guo X, Goff SP (Sep 2002). "Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein". Science. 297 (5587): 1703–6. doi:10.1126/science.1074276. PMID 12215647. S2CID 42188205.
  6. ^ Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7. doi:10.3892/ijo.23.2.541. PMID 12851707.
  7. ^ a b "Entrez Gene: ZC3HAV1 zinc finger CCCH-type, antiviral 1".
  8. ^ Ficarelli, Mattia; Neil, Stuart J.D.; Swanson, Chad M. (29 September 2021). "Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System". Annual Review of Virology. 8 (1): 265–283. doi:10.1146/annurev-virology-091919-104213. ISSN 2327-056X. PMID 34129371.

Further reading

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