Zinc finger CCCH domain-containing protein 11A is a protein that in humans is encoded by the ZC3H11A gene.[4][5] ZC3H11A is a part of the transcription export (TREX) complex and plays a role in exporting of mRNAs from nucleus to cytoplasm.[6] It is considered as stress-induced nuclear protein and maintains mRNAs exporting when the cells are under stress.[7] Loss of functioning of ZC3H11A gene in HeLa cells results in abortion of the replication of nuclear replicating viruses but not cytoplasmic replicating viruses.[8] It is discovered that ZC3H11A is significant for viability and metabolic regulation of mouse embryo[9]

ZC3H11A
Identifiers
AliasesZC3H11A, ZC3HDC11A, zinc finger CCCH-type containing 11A
External IDsOMIM: 613513; MGI: 1917829; HomoloGene: 8888; GeneCards: ZC3H11A; OMA:ZC3H11A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001276767
NM_144530
NM_001357228

RefSeq (protein)

NP_001263696
NP_653113
NP_001344157

Location (UCSC)Chr 1: 203.8 – 203.85 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058673Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.
  5. ^ "Entrez Gene: ZC3H11A zinc finger CCCH-type containing 11A".
  6. ^ Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R (23 August 2012). "The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export". PLOS ONE. 7 (8): e43804. Bibcode:2012PLoSO...743804F. doi:10.1371/journal.pone.0043804. PMC 3426524. PMID 22928037.
  7. ^ Younis S, Kamel W, Falkeborn T, Wang H, Yu D, Daniels R, et al. (April 2018). "Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth". Proceedings of the National Academy of Sciences of the United States of America. 115 (16): E3808–E3816. Bibcode:2018PNAS..115E3808Y. doi:10.1073/pnas.1722333115. PMC 5910864. PMID 29610341.
  8. ^ Younis S, Kamel W, Falkeborn T, Wang H, Yu D, Daniels R, et al. (April 2018). "Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth". Proceedings of the National Academy of Sciences of the United States of America. 115 (16): E3808–E3816. Bibcode:2018PNAS..115E3808Y. doi:10.1073/pnas.1722333115. PMC 5910864. PMID 29610341.
  9. ^ Younis S, Jouneau A, Larsson M, Oudin JF, Adenot P, Omar J, et al. (June 2023). "Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes". Proceedings of the National Academy of Sciences of the United States of America. 120 (23): e2216799120. Bibcode:2023PNAS..12016799Y. doi:10.1073/pnas.2216799120. PMC 10266022. PMID 37252988.

Further reading

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