YchF-GTPase C terminal protein domain

In molecular biology, this protein domain is found at the C terminus of the GTP-binding protein, YchF-GTPase found in both prokaryotes and eukaryotes.

C terminal domain of YchF-GTPase
ychf protein (hi0393)
Identifiers
SymbolYchF-GTPase_C
PfamPF06071
Pfam clanCL0072
InterProIPR013029
SCOP21ni3 / SCOPe / SUPFAM
CDDcd04867
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Function

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The function of this protein domain remains unknown, however, it is putatively thought to be necessary for ribosome function or for signal transduction from the ribosome to downstream targets. Additionally, GTPases are often described as a molecular switch.[1]

Structure

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The crystal structure of Haemophilus influenzae has been determined.[2] This protein consists of three domains, of which the C-terminal domain which is composed of a six-stranded half-barrel curved around an alpha helix.

References

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  1. ^ Caldon CE, Yoong P, March PE (2001). "Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function". Mol Microbiol. 41 (2): 289–97. doi:10.1046/j.1365-2958.2001.02536.x. PMID 11489118.
  2. ^ Teplyakov A, Obmolova G, Chu SY, Toedt J, Eisenstein E, Howard AJ, Gilliland GL (July 2003). "Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid". J. Bacteriol. 185 (14): 4031–7. doi:10.1128/jb.185.14.4031-4037.2003. PMC 164861. PMID 12837776.
This article incorporates text from the public domain Pfam and InterPro: IPR013029