XJB-5-131 is a synthetic antioxidant. In a mouse model of Huntington's disease, it has been shown to reduce oxidative damage to mitochondrial DNA, and to maintain mitochondrial DNA copy number.[1] XJB-5-131 also strongly protects against ferroptosis, a form of iron-dependent regulated cell death.[2]
![]() | |
Legal status | |
---|---|
Legal status |
|
Identifiers | |
PubChem CID | |
ChemSpider | |
ChEBI | |
Chemical and physical data | |
Formula | C53H80N7O9 |
Molar mass | 959.263 g·mol−1 |
3D model (JSmol) | |
| |
|
References
edit- ^ Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, et al. (November 2012). "Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease". Cell Reports. 2 (5): 1137–42. doi:10.1016/j.celrep.2012.10.001. PMC 3513647. PMID 23122961.
- ^ Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P (September 2016). "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis". ACS Central Science. 2 (9): 653–659. doi:10.1021/acscentsci.6b00199. PMC 5043442. PMID 27725964.