Wyrick is a surname. Notable people with the surname include:

  • Blair Wyrick of Single File, a band from Westminster, Colorado
  • Charles Wyrick, Oklahoma Senator from District 1, which includes Craig, Delaware and Ottawa counties
  • Jimmy Wyrick (born 1976), former American football cornerback in the National Football League
  • Mabel Martin Wyrick (1913–2003), writer whose published books include If Quilts Could Talk
  • Steve Wyrick (born 1970), American magician from Garland, Texas
  • Travis Wyrick, music producer and owner of Lakeside Studios in Knoxville, Tennessee
  • V. Neil Wyrick (born 1928), writer and minister in the Presbyterian Church (USA)

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