Wolffe is a surname of English and Jewish (Ashkenazic) origin. Variant of Wolf, Wolff or Wolfe . Notable people with the surname include:

  • Alan Wolffe (1959–2001), British cell biologist
  • Jabez Wolffe (1876–1943), British swimmer who attempted to swim the English Channel many times
  • James Wolffe (born 1962), Scottish lawyer
  • Richard Wolffe (born 1968), British-American journalist, MSNBC commentator and author
  • Andrew Wolffe (born1964), Scottish Designer

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