Wise is a surname. Notable people with the surname include:
- Anna Wise (born 1991), American singer
- Audrey Wise (1935–2000), United Kingdom politician
- Bernhard Wise (1858–1916), Australian politician
- Bob Wise (born 1948), American politician
- Brownie Wise (1913–1992), American saleswoman who developed "party plan" marketing
- Christopher Wise (born 1961), American author
- Cody Wise, American singer
- Daniel Wise (disambiguation), several people, including
- Daniel Wise (American football) (born 1996), American football player
- Daniel Wise (author) (1813–1898), Methodist Episcopal clerical author
- Daniel Wise (playwright), American contemporary playwright, producer, and author
- Daniel Wise (mathematician) (born 1971), American mathematician
- David Wise (disambiguation), several people, including
- David Wise (composer), British video game music composer
- David Wise (cricketer) (born 1963), English cricketer
- David Wise (freestyle skier) (born 1990), American Olympic gold medalist
- David Wise (journalist) (1930–2018), American investigative journalist and writer
- David Wise (writer) (1955–2020), American television writer
- Deatrich Wise (born 1965), American football player
- Deatrich Wise Jr. (born 1994), American football player
- Dennis Wise (born 1966), English footballer
- DeWayne Wise (born 1978), American baseball player
- Doc Wise (born 1967), American football player
- Dwight Wise (1930–2020), American politician.
- Ernie Wise (1925–1999), British comedian
- Frank Wise (1897–1986), Australian politician
- Frank Wise (British politician) (1885–1933), British politician and economist
- Frank C. Wise (1864–1956), American politician from Ohio
- Fred Wise (disambiguation), several people
- Fred Wise (physician) (1881–1950), American dermatologist
- Fred Wise (songwriter) (1915–1966), American lyricist who wrote songs for Elvis Presley
- Frederick Wise, 1st Baron Wise (1887–1968), British Labour Party politician
- Fredric Wise (1871–1928), British Conservative Party politician
- George Wise (disambiguation), several people, including
- George Wise (Australian politician) (1853–1950), Australian politician and solicitor
- George Wise (rugby union) (1904–1971), New Zealand rugby union player
- George D. Wise (Union) (1816–1881), Union Army officer during the American Civil War
- George D. Wise (politician) (1831–1898), U.S. Representative from Virginia
- George S. Wise (1906–1987), American Jewish sociologist
- Glenn M. Wise American politician
- Henry Wise (disambiguation), several people, including
- Henry Wise (footballer) (born 2000), English professional footballer
- Henry Wise (gardener) (1653–1738), English gardener, designer, and nurseryman
- Henry Wise (merchant) (1802–1866), English mariner and merchant
- Henry Wise (publisher) (1835–1922), New Zealand publisher
- Henry A. Wise (1806–1876), Governor of Virginia
- Henry A. Wise (attorney), United States Attorney for the Southern District of New York (1909–13)
- Henry Wise Jr. (1920–2003), American physician and World War II Tuskegee Airman fighter pilot
- Henry A. Wise (New York state senator) (1906–1982), New York politician
- Henry Augustus Wise (1819–1869), author and U.S. Naval Officer
- Henry Seiler Wise (1909–1982), United States federal judge
- Henry Christopher Wise (politician) (1806–1883), English politician
- Isaac Mayer Wise (1819–1900), American Reform rabbi and author
- Jake Wise (born 2000), American professional ice-hockey player
- James H. Wise (politician) (1912–1976), American politician
- John Wise (disambiguation), several people, including:
- John Wise (Australian politician) (1856–1942), New South Wales politician
- John Wise (balloonist) (1808–1879), American ballooning pioneer
- John Wise (Canadian politician) (1935–2013)
- John Wise (clergyman) (1652–1725), Massachusetts divine who protested taxation
- John Wise (footballer) (born 1954), Australian footballer
- John Wise (Canadian politician) (1935–2013), Progressive Conservative MP and federal Minister of Agriculture
- John Wise (sport shooter) (1901–1971), Australian, competed at the 1948 Olympic Games
- John Wise (Virginia politician) (fl. 1768–1812), Speaker of Virginia House of Delegates
- John A. Wise (1939–2011), American scientist
- John Ayshford Wise (1810–1865), British MP for Stafford
- John Henry Wise (1868–1937), Hawaiian politician
- John Richard de Capel Wise (1831–1890), British writer
- John Sergeant Wise (1846–1913), American Congressman
- Josh Wise (born 1983), NASCAR driver
- Julian Stanley Wise (1900–1985), volunteer rescue organization founder
- Korey Wise (born 1972), American activist
- Kurt Wise, American creationist
- Leo Wise (1849–1933), American newspaper editor and publisher
- Louise Waterman Wise (1874–1974), American social worker and artist
- Mark B. Wise (born 1953), physicist
- Matt Wise (born 1975), baseball player
- Max Wise (born 1975), American former FBI agent, serving as a member of the Kentucky Senate
- Michael Wise (disambiguation), several people, including
- Michael John Wise (1918–2015), British geographer
- Mike Wise (American football) (1964–1992), American football defensive end
- Mike Wise (American columnist), sports and feature writer for The Washington Post
- Mike Wise (politician), member of the Ohio House of Representatives
- Rev. Percy W. Wise "Canon Wise" (1870–1950), Anglican priest in South Australia
- Ray Wise (born 1947), American actor
- Richard Alsop Wise (1843–1900), US politician of political family
- Rick Wise (born 1945), American baseball player
- Robert Wise (disambiguation), several people, including
- Robert Wise (1914–2005), American film producer and director
- Bob Wise (born 1948), U.S. governor of West Virginia
- Robert Russell "Chubby" Wise (1915–1996), American bluegrass fiddler
- Robert C. Wise (born 1925), Pennsylvania politician
- Robert Wise, chairman and managing director of the Wise Music Group (formerly Music Sales Group), sheet music publishers
- Robert E. Wise, American architect, founder of the Cramer, Bartlett & Wise firm in Los Angeles in the early 1900s
- Seelig Wise (1913–2004), American farmer and politician
- Stephen Wise (disambiguation), several people, including
- Stephen Samuel Wise (1874–1949), American rabbi and Zionist leader
- Stephen R. Wise (born 1941), member of the Florida Senate
- Steven M. Wise (born 1952), American legal scholar
- Sue Wise (born 1953), English feminist author
- Tim Wise, American anti-racist activist
- Thomas Wise (disambiguation), several people
- Sir Thomas Wise (died 1630) (died 1629), English politician, MP for Bere Alston, 1621
- Thomas James Wise (1859–1937), manuscript forger
- Thomas Wise (died 1641) (c. 1605 – 1641), English politician
- Thomas Wise (priest) (1671–1726), clergyman of the Church of England
- Thomas A. Wise (1865–1928), American actor and president of The Lambs
- Thomas Dewey Wise (born 1939), American politician in the state of South Carolina
- Tom Wise (born 1948), Independent and UKIP member of the European Parliament
- Wes Wise (1928-2022), American journalist and politician
- Willie Wise, American basketballer born 1947
- William Wise (disambiguation), several people, including
- William Furlong Wise, British Naval officer
- William Wise III, American basketballer born 1992
- Willy Wise, American boxer