Winterbottom's sign is a swelling of lymph nodes (lymphadenopathy) along the posterior cervical lymph node chain, associated with the early phase of African trypanosomiasis (African sleeping sickness), a disease caused by the parasites Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. It may be suggestive of cerebral infection.[1] Winterbottom reported about the slave traders who, apparently aware of the ominous sign of swollen cervical lymph glands, used to palpate the necks of the slaves before buying them.[2][3][4]
Winterbottom's sign | |
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Differential diagnosis | African trypanosomiasis |
![A sketch of two women suffering with lumps on the sides of their necks](http://upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Signo_de_Winterbottom.jpg/220px-Signo_de_Winterbottom.jpg)
The sign was first reported by the English physician Thomas Masterman Winterbottom in 1803.[citation needed]
References
edit- ^ Ormerod WE (October 1991). "Hypothesis: the significance of Winterbottom's sign". J Trop Med Hyg. 94 (5): 338–40. PMID 1942213.
- ^ "The history of sleeping sickness". Archived from the original on March 23, 2008.
- ^ Miles, Tom. "The Winterbottom Catalogue". www.bl.uk. Archived from the original on 2019-03-18. Retrieved 2009-03-16.
- ^ Cox F. History of sleeping sickness (African trypanosomiasis). Infectious Disease Clinics of North America - Volume 18, Issue 2 (June 2004)