Wikipedia:USEP/Courses/JHU MolBio Ogg FA13/Group 81C

Group 81C

This is a group page for the Johns Hopkins Molecular Biology course. This group will be working on the article Cotransporter.

Use the talk page here to collaborate as a group, when learning to use and navigate Wikipedia, assessing articles, or for any other topic.

Use this page (not the talk page) for article assessments; rationale for selecting an article; etc (as specified in the milestone summary chart.

Please create a new section here for each of those assignments.

Initial article assessments from LutyeusMaximus

Neutral Mutation

The Wikipedia article can be found here. The article is currently considered a stub article with high importance and it doesn't look like anyone is working on the article at the moment (the last entry on the talk page was in 2007). The article covers to top very broadly and briefly. There are no references. To improve the article we will need to find references, add in-line citations, expand and broaden the topic, add supporting materials like images and visuals and finally add a well defined structure.

Possible Sources

Lodish, H., Berk, A., Amon, A., Bretscher, A., Kaiser, C., Kriefer, M., et al. (2013). Molecular Cell Biology (7th ed.). New York: W.H. Freeman and Co..

Watson, J.D., Baker, T.A., Bell, S.P., Gann, A., Levine, M., Losick, R. (2014) Molecular Biology of the Gene. (7th ed). New York: Cold Spring Harbor Laboratory Press.

Nei, M., Suzuki, Y., & Nozawa, M. (2010). The Neutral Theory Of Molecular Evolution In The Genomic Era. annual review of genomics and human genetics, 11(1), 265-289. here

Martincorena, I., Seshasayee, A., & Luscombe, N. (2012). Evidence of non-random mutation rates suggest an evolutionary risk management strategy. Nature, 485(7396), 95-98. here

Cotransporter

The Wikipedia article can be found here. The article is also currently considered a stub article with high importance. There are no entries on the talk page, so doesn't look like anyone is working on this article either. The article covers to top very broadly and briefly. The article does have links to other articles and provides some background. The article also does have a see also section. There are a few references. To improve the article we will need to do very similar work as with the Neutral Mutation article. We will need to find additional references, add in-line citations, expand and broaden the topic, add supporting materials like images and visuals and finally add a well defined structure.

Possible Sources

Lodish, H., Berk, A., Amon, A., Bretscher, A., Kaiser, C., Kriefer, M., et al. (2013). Molecular Cell Biology (7th ed.). New York: W.H. Freeman and Co..

Watson, J.D., Baker, T.A., Bell, S.P., Gann, A., Levine, M., Losick, R. (2014) Molecular Biology of the Gene. (7th ed). New York: Cold Spring Harbor Laboratory Press.

Gao, X., Lu, F., Zhou, L., Dang, S., Sun, L., Li, X., et al. (2009). Structure And Mechanism Of An Amino Acid Antiporter. Science, 324(5934), 1565-1568. here

Gao, X., Zhou, L., Jiao, X., Lu, F., Yan, C., Zeng, X., et al. (2010). Mechanism Of Substrate Recognition And Transport By An Amino Acid Antiporter. Nature, 463(7282), 828-832. here

Initial Article Assessment from Harshil Patel

Neutral Mutation

The article assessed is on Neutral mutation. This article has a very basic description on the topic and is classified as a Stub article. The article has few issues - it lacks in-line citations and references to support the content of the article, this article has not been attended since a long time. Since there is not much content and citation in this article it would need lot of work to bring the level up to A-class. Igenes (talk) 18:56, 1 October 2013 (UTC)

Possible Sources

Watson, J.D., Baker, T.A., Bell, S.P., Gann, A., Levine, M., Losick, R. (2014) Molecular Biology of the Gene. (7th ed). New York: Cold Spring Harbor Laboratory Press.

H. Tachida, H., (1991), A Study on a Nearly Neutral Mutation Model in Finite Populations, Genetics, 128(1): 183–192.

Viral Transformation

The article on Viral Transformation is classified as a Stub article and needs some effort in put the content together. It has no reference to support the content of the article adding to that there is no activity in the talk page which shows that this article has been edited. This article is also classified as high importance as the topic is likely to attract more people. The topic on Viral Transformation is popular in cancer biology.Igenes (talk) 05:53, 15 October 2013 (UTC)

Possible Sources

Watson, J.D., Baker, T.A., Bell, S.P., Gann, A., Levine, M., Losick, R. (2014) Molecular Biology of the Gene. (7th ed). New York: Cold Spring Harbor Laboratory Press.

Jenny Bangham, (2006), A step towards viral transformation, Nature Reviews Cancer 6, 254-255.

Initail Article Assessment from Sridenour

Terminator (genetics)

This article can be found here and so far can be classes as a Stub article since it has just the basics with a definition of the topic and a few other factual statements. It has a couple of users on the talk page but they mainly discussed that the article was weak and needed work. Possible Sources:

Cambray, G., Guimaraes, J.C, et al. (2013). Measuring and Modeling of Intrinsic Transcription Terminators. Nucleic Acids Research 41(9), 5139-5148 [1]

Kryuchkova, P., et al, (2013). Two-step model of stop codon recognition by eukaryotic release factor eRF1. Nucleic Acids Research. 41(8): 4573–4586. [2]

Extrachromosomal DNA

This article can be found here and is a stub class article as well. It does have a little more information on the page but has no citations to back up the material already there. There is no comments on the talk page. Possible Sources:

Watson, J.D., Baker, T.A., Bell, S.P., Gann, A., Levine, M., Losick, R. (2014) Molecular Biology of the Gene. (7th ed). New York: Cold Spring Harbor Laboratory Press.

Cohen, S., Agmon, N., Sobol, O., Segal, D. (2010). Extrachromosolmal Circles of Satellite and 5S Ribosomal DNA in Human Cells. Mobile DNA. [3]

Talk page of the article

The talk page of this article shows that it is a part of WikiProject Genetics and WikiProject Molecular and Cellular Biology. WikiProject Genetics classified this article under Stub and rated under unknown category. Whereas the WikiProject Molecular and Cellular Biology classified this article under Stub and rate it under High category. Which means that this subject of the article is usually examined by lower-division College and briefly discussed at the high school level. Igenes (talk) 18:56, 1 October 2013 (UTC)

Article Selection Rationale

We choose to edit the article on cotransporters for a few different reasons. The article is a stub article with high importance, so we know we will have a lot of work to do, but this allows us to have full control over the design of the article. The article has some general structure already layed out with a See Also and References sections already started. The talk page has no entries so it doesn't seem like anyone else is editing the page and we won't offend anybody by working on the page. Two of our members are familiar with cotransporters as they have taken(Sonya) or are taking currently(Seth) Advanced Cell Bio 1 and therefore already have sources and possible images that can be used for updating the article. We know to improve the article we will need to expand and broaden the topic by finding additional references. Using these additional references we will add in-line citations, and add supporting materials like images and visuals. We have already briefly discussed adding a section about common cotransporters in the human body and some diseases associated with mutations in cotransporters. There are a few references cited for information already in the article, so as a precautionary step we will have to assure that the references are correct. Another rationale in selecting this article is that we predict this article would be viewed by large amount of high school and college students, therefore developing the content of this article would be useful to lot of people.

Unit 8 Progress Report

Sridenour:

• Began initial intro for article distinguishing the two main types of cotransporters
• Gave initial description of how cotransporters work
• Added previously proposed picture from wikimedia commons for the types of transporters Sridenour (talk) 19:03, 27 October 2013 (UTC)

Harshil:

• Started writing content on the background of cotransporter article - added content on the person who discovered cotransport system.
• Uploaded a picture of the person who discovered the cotransporter system in cells - picture used was from wikipedia commons.Igenes (talk) 01:28, 28 October 2013 (UTC)

Unit 10 Progress Report

Seth

• fixed edits suggested by reviewers
• added content for antiporters and symporters, including citations
• added images to wikimedia commons for antiporters, symporters and Oleg Jardetzky
• added those images to article page and adjusted alignment with page breaks
• proposed we find a new image for beginning of article LutyeusMaximus (talk) 16:42, 9 November 2013 (UTC)

Sonya

• added caption to first picture in lead
• responded to reviewers as to which edits I fixed
• Added specific examples of antiporters and symportersSridenour (talk) 16:50, 10 November 2013 (UTC)

Harshil

• Made some edits and changed the content in the background section.
• Added a new image of Dr. R.K. Crane and his sketch in wikimedia commons
• Changed the picture in the background section.
• Fixed the first citation that was suggested to be fixed.
• Added a new section called 'Diseases associated with Cotransporters'
• Created a table under 'Diseases associated with Cotransporters'Igenes (talk) 23:48, 16 November 2013 (UTC)

Unit 12 Progress Report

Seth

• fixed breaks on page, a bot changed the page and removed them causing things not to line up
• removed "Co-Transport" from the see also
• removed picture of Oleg Jardetzky, didn't go to wikimedia commons, but also since we decided to remove the image of dr crane from the first section it made sense to remove dr jardetzky also
• wiki-linked more subjects in article sections
• clarified mechanism section per comments
• edited main page image, added Cotransporters label, re-uploaded to wikimedia commons

LutyeusMaximus (talk) 00:05, 22 November 2013 (UTC)

Sonya

• reworded lead section as per reviewers request
• added a sentence in that was suggested in Klorthos review
• removed some re-occuring wikilinks

Sridenour (talk) 14:58, 21 November 2013 (UTC)

• Moved History section up towards top of article
• Added wikilinks where possible in disease table
• added Cystic Fibrosis to See Also section
• worked on wording some in About section
• added some suggestion wikilinks in the about section

Sridenour (talk) 19:55, 26 November 2013 (UTC)

Harshil

• Reformatted the background section as suggested by reviewers
• Created a new section called "Disease associated with Cotransporters", under which a table was created and updated.
• Fixed the citation problem mentioned.
• Uploaded a picture(Dr. Robert K Crane) in wikimedia commons and used it in the History section.
• Responded to per reviews.

Igenes (talk) 00:50, 22 November 2013 (UTC)

Final Progress Report

Sonya

• Added more wikilinking to the disease table after correcting spelling.
• Moved the discussion of the Na-K-2Cl Symporter to the newly added section of examples of cotransporters. Sridenour (talk) 15:54, 6 December 2013 (UTC)
• Added the K+Cl- symporter to the example section.
• Reworded intro as per reviewers request
• Removed italics from Example section as per reviewers request
• Corrected grammar mistakes pointed out by reviewers Sridenour (talk) 23:41, 10 December 2013 (UTC)

Overall Major Additions-Sridenour

• Drafted and edited the introduction section
• Added two examples to the types of cotransporter sections
• Provided wikilinking where possible for diseases within table
• Added first picture with all three transporters
• Added Cystic Fibrosis to See Also section
• Fixed layout of page as suggested from reviewers Sridenour (talk) 23:44, 10 December 2013 (UTC)

Seth

• Changed the About section label to Background
• Removed the External Links section at the bottom, since the links were broken anyway
• Removed the Membrane transport protein: ion pumps, ATPases / ATP synthase (TC 3A2-3A3) table at the bottom because cotransporters are not ATPases
• Clarified opening sentence
• added more wikilinks to disease table
• searched for an image containing cotransporters displaying conformational changes but didn't find any on wikimedia commons, will search other sources

Overall Work On Article/Acknowledgements

• Proposed the initial structure for the article
• Added the mechanism section
• Added the Antiporters Section
• Added the Symporters Section
• Edited the Cotransporter image to contain a bracket around the symporter and antiporter - per Klortho's suggestion
• Cropped the Cotransporter image for the single larger antiporter image
• Cropped the Cotransporter image for the single larger symporter image
• Just a general thank you to all our reviewers they were very helpful at pointing out subjects that needed to be clarified

LutyeusMaximus (talk) 02:24, 10 December 2013 (UTC)

Harshil

• Fixed alignment issue under 'Types of Cotransporter'.
• Added four examples under 'Types of Cotransporter'.
• Edited the 'History' section.
• Edited minor errors suggested by reviewers.

Overall Work on Article

• Added the 'Background' section
• Added the 'History' section
• Added the 'Diseases of Cotransporter' section
• Created the table under 'Disease of Cotransporter' section
• Added picture of Dr. Crane into wikimedia commons and to the article.
• Added a subsection called 'Examples of Cotransporters'.
• Added wikilinks in the sections I developed.

Igenes (talk) 03:12, 13 December 2013 (UTC)