Wikipedia:Today's featured article/requests/Beta-Hydroxy beta-methylbutyric acid

Beta-Hydroxy beta-methylbutyric acid

{{subst:TFAR top|passed=yes|date=May 28, 2018|monthyear=March 2018}}

β-Hydroxy β-methylbutyric acid (HMB) is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS. In healthy adults, supplementation with HMB has been shown to increase exercise-induced gains in muscle size, muscle strength, and lean body mass, reduce skeletal muscle damage from exercise, improve aerobic exercise performance, and expedite recovery from exercise. Medical reviews and meta-analyses indicate that HMB supplementation also helps to preserve or increase lean body mass and muscle strength in individuals experiencing age-related muscle loss. HMB produces these effects in part by stimulating the production of proteins and inhibiting the breakdown of proteins in muscle tissue. HMB is a metabolite of L-leucine and is produced in the body through oxidation of the ketoacid of L-leucine (α-ketoisocaproic acid). Since only a small fraction of L-leucine is metabolized into HMB, pharmacologically active concentrations of the compound in blood plasma and muscle can only be achieved by supplementing HMB directly. (Full article...)

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• Main editors: Me (Seppi333) & Boghog
• Promoted: 23 March 2018
• Reasons for nomination: The last time a pharmacology or molecular and cell biology article was on the main page was 2 years ago. There's no date relevance for this nomination. This is my second TFA nomination. This is not a vital article. There's 11 equivalent articles on HMB across all language versions of Wikipedia.
   • On an unrelated note, this blurb is 1224 characters. I can probably cut 25–50 characters without affecting the coherence if that's really an issue. Every sentence was copy/pasted from the first 2 paragraphs of this article's lead.
• Support as nominator. Seppi333 (Insert 2¢) 04:32, 25 March 2018 (UTC)
• Support. What Seppi says. I supported on prose at FAC. I can work on the blurb now if you like, but I usually wait until the article has been selected for TFA. - Dank (push to talk) 13:08, 25 March 2018 (UTC)

  That's fine with me. :) Seppi333 (Insert 2¢) 20:03, 25 March 2018 (UTC)

• Support- we haven't had something like this as TFA for a while. Mojo0306 (talk) 21:05, 26 March 2018 (UTC)
• support a very good article--Ozzie10aaaa (talk) 00:44, 27 March 2018 (UTC){{subst:TFAR bottom|passed=yes}}