Wikipedia:Reference desk/Archives/Science/2014 November 15

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November 15

Questions about Coenzyme A

1. Why is it seemingly so rare as a dietary supplement?
2. Do you find any theoretical reason in the claim CoA supplementation increase Lipolysis in some rare cases of "low" lipolysis in compare to "high" Glycolysis (Please, take your time to handle this question and try not to be too much skeptic or general in your answer), Thanks to all the helpers. Ben-Natan (talk) 09:32, 15 November 2014 (UTC)

Humans, like all animals, can synthesize their own Coenzyme-A. As a result, it is very rare to be considered deficient in CoA except in cases of severe malnutrition. In addition, CoA does not handle digestion well, so most of the CoA that you eat (or attempt to consume as supplements) will usually be broken down into smaller molecules before entering the blood. Given that, most of the time people choose to supplement with precursor molecules, such as vitamin B5 (pantothenic acid) or panthenol, which the body knows how to turn into CoA rather than supplement with CoA directly. Dragons flight (talk) 18:38, 15 November 2014 (UTC)