Whedon is a surname. Notable people with the surname include:

Real people

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  • Daniel Denison Whedon (1808 – 1885), American Methodist minister
  • Frances L. Whedon (1902 – 1998), American meteorologist
  • Jed Whedon (born 1975), an American screenwriter and musician; Tom Whedon and brother of Joss Whedon
  • John Whedon (1905 – 1991), an American writer for television; Tom Whedon's father and Joss Whedon's grandfather
  • Joss Whedon (born 1964), an American writer, director, and executive producer for television
  • Tom Whedon (1932 – 2016), an American writer for television; Joss Whedon's father
  • Zack Whedon, an American writer for television; son of Tom Whedon and brother of Joss Whedon

Fictional characters

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  • Evangeline Whedon, a fictional character in the Marvel Comics Universe
  • Joe Whedon, a fictional character on the primetime show Brothers & Sisters
  • Sarah Whedon, a fictional character on the primetime show Brothers & Sisters