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Wetland virus or WELV is a tick borne Orthonairovirus which can infect humans. It can produce fever, headache, dizziness, malaise, arthritis and less commonly petechiae, localized lymphadenopathy. Complications may include neurological symptoms.[1]
| Wetland virus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Ellioviricetes |
| Order: | Bunyavirales |
| Family: | Nairoviridae |
| Genus: | Orthonairovirus |
| Virus: | Wetland virus
|
Virology
editThe Wetland virus orthonairovirus (WELV) is a member of the genus Orthonairovirus, family Nairoviridae[1] of RNA viruses. It was first identified in 2019 in a Chinese person in Jinzhou, Liaoning province NorthEastern China after a visit to a wetland park in Yakeshi, Inner Mongolia. Three different strains were identified one from the patient and two from ticks.[1]
Its sequence is most similar to the Tofla virus from Japan.[1]
Hosts and transmission
editThe Wetland virus was found in mice, sheep, pigs, and horses, but not dogs or cattle. It was found in about 2% of 14,500 different ticks in Northeast China with the highest prevalence (6%) in Haemaphysalis concinna.[1]
experimental infection showed that WELV caused lethal disease even in immunocompetent mice, unlike the remainder of the viruses in Nairoviridae family.[1]
Signs and symptoms
editSymptoms of infection with the Wetland virus are fever, headache, dizziness, malaise, myalgia (muscle pain), arthritis, and back pain. Less commonly there are petechiae and localized lymphadenopathy.[1] One person also had severe neurological symptoms, but all recovered without sequelae.[1] Symptoms and signs resemble those of Crimean–Congo hemorrhagic fever, and the differential diagnosis includes severe fever with thrombocytopenia syndrome and spotted fever.[1]
Laboratory testing in the investigation in China included reverse-transcriptase–polymerase-chain-reaction Rt pcr assay indirect immunofluorescence assays, enzyme-linked immunosorbent assays (ELISAs), or microneutralization assays. Of twenty Wetland virus patients 3 had a tick borne disease bacterial coinfection (spotted fever group Rickettsia in 2 and Borrelia burgdorferi in 1).[1]
References
edit- ^ a b c d e f g h i j Zhang, Xiao-Ai; Ma, Yi-Dan; Zhang, Yun-Fa; Hu, Zhen-Yu; Zhang, Jing-Tao; Han, Shuo; Wang, Gang; Li, Shuang; Wang, Xi; Tang, Fang; Liang, Wen-Jun; Yuan, Hong-Xia; Zhao, Jia-Qi; Jiang, Lan-Fen; Zhang, Lei (2024-09-05). "A New Orthonairovirus Associated with Human Febrile Illness". New England Journal of Medicine. 391 (9): 821–831. doi:10.1056/NEJMoa2313722. ISSN 0028-4793. PMID 39231344.
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