WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.[5][6][7]

WIPI1
Identifiers
AliasesWIPI1, ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1
External IDsOMIM: 609224; MGI: 1261864; HomoloGene: 117983; GeneCards: WIPI1; OMA:WIPI1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017983
NM_001320772

NM_145940

RefSeq (protein)

NP_001307701
NP_060453

NP_666052

Location (UCSC)Chr 17: 68.42 – 68.46 MbChr 11: 109.46 – 109.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure and function

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WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.[5][7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070540Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041895Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WD repeat domain".
  6. ^ Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
  7. ^ a b Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.