WBP2

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.

WBP2
Identifiers
Aliases	WBP2, WBP-2, GRAMD6, WW domain binding protein 2, DFNB107
External IDs	OMIM: 606962; MGI: 104709; HomoloGene: 32160; GeneCards: WBP2; OMA:WBP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 75,845,699 bp End 75,856,507 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 115,969,399 bp End 115,977,821 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum prefrontal cortex C1 segment right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex cingulate gyrus anterior cingulate cortex Top expressed in primary visual cortex neural layer of retina dentate gyrus of hippocampal formation granule cell superior frontal gyrus perirhinal cortex cerebellar cortex entorhinal cortex right kidney granulocyte CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin DNA binding protein binding RNA polymerase II core promoter sequence-specific DNA binding transcription coactivator activity estrogen receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus cytoplasm Biological process positive regulation of histone H3-K14 acetylation positive regulation of transcription by RNA polymerase II establishment of protein localization epigenetic maintenance of chromatin in transcription-competent conformation cellular response to estrogen stimulus response to progesterone positive regulation of intracellular estrogen receptor signaling pathway response to estrogen progesterone receptor signaling pathway transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23558 22378 Ensembl ENSG00000132471 ENSMUSG00000034341 UniProt Q969T9 P97765 RefSeq (mRNA) NM_012478 NM_001330499 NM_001348170 NM_016852 NM_001347642 NM_001361446 RefSeq (protein) NP_001317428 NP_036610 NP_001335099 NP_001334571 NP_058548 NP_001348375 Location (UCSC) Chr 17: 75.85 – 75.86 Mb Chr 11: 115.97 – 115.98 Mb PubMed search
Wikidata
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The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.

Further reading

• Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
• Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi:10.1074/jbc.272.27.17070. PMID 9202023.
• Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nitsch R, Di Palma T, Mascia A, Zannini M (2004). "WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8". Biochem. J. 377 (Pt 3): 553–60. doi:10.1042/BJ20031233. PMC 1223889. PMID 14531730.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Dhananjayan SC, Ramamoorthy S, Khan OY, et al. (2006). "WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors". Mol. Endocrinol. 20 (10): 2343–54. doi:10.1210/me.2005-0533. PMID 16772533.