Valderrama is a Spanish surname. Notable people with the surname include:
- Andrea Valderrama, American politician
- Carlos Valderrama (footballer), Colombian football (soccer) player
- Carlos Valderrama (baseball), Venezuelan baseball player
- Gustavo Valderrama, Venezuelan volleyball player
- Juan Valderrama, Spanish singer
- Wilmer Valderrama, American actor
- Eugeni Valderrama (born 1994), Spanish footballer