VP1 or VP-1 may refer to:
VP1:
- Viral Protein 1, a name used for the largest, most abundant, or first discovered protein component of the capsids of several virus families
- Major capsid protein VP1, a main component of the polyomavirus capsid
- VP1, a virtual machine architecture conceptually similar to Java
VP-1:
- Evans VP-1 Volksplane, an aircraft designed for amateur construction
- VP-1, an active patrol squadron of the United States Navy, the fifth Navy squadron to be designated VP-1
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