User talk:Swalk22/sandbox

Your references look good. The current article needs more mechanisms listed and explained so I think this is a good starting direction. Do arrestins play a role in other desensitization mechanisms or just the adrenergic mechanism listed?Gingerscotch (talk) 15:48, 26 October 2017 (UTC)

Oh, to answer your question (which I forgot about), arrestins do play a role in other mechanisms. I was specifically reading into receptor endocytosis, but arrestin binding usually follow after the channel phosphorylation which then affects everything else. Sadly, this is not the case 100% of the time which complicates the issue.Swalk22 (talk) 18:52, 24 November 2017 (UTC)

Also, do you think I should talk about ways to block each mechanism? e.g. heparin inhibits receptor phosphorylation and hypertonic sucrose inhibits endocytosis.Swalk22 (talk) 22:06, 25 November 2017 (UTC)

Also (for Gingerscotch), I ended up uploading what I wrote to the wiki article itself so you can see most of the final product. There is another person who has monitored the page and edited what I wrote a lot as well.Swalk22 (talk) 00:22, 3 December 2017 (UTC)

Sorry for not responding sooner. It looks good. The only thing that was initially not entirely clear for me was the connection between endocytosis and desensitization but as I read on, the removal of receptors from the cell membrane made more sense. Gingerscotch (talk) 05:53, 5 December 2017 (UTC)