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MakesNotSense

Joined 30 June 2019
Latest comment: 4 years ago by MakesNotSense in topic What does this have to do with trazodone?

Welcome edit

Latest comment: 4 years ago1 comment1 person in discussion
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– the WikiProject Medicine team Doc James (talk · contribs · email) 22:38, 30 June 2019 (UTC)Reply

References edit

Latest comment: 4 years ago1 comment1 person in discussion
 
 
Just follow the steps 1, 2 and 3 as shown and fill in the details

Thank you for contributing to Wikipedia. Remember that when adding content about health, please only use high-quality reliable sources as references. We typically use review articles, major textbooks and position statements of national or international organizations (There are several kinds of sources that discuss health: here is how the community classifies them and uses them). WP:MEDHOW walks you through editing step by step. A list of resources to help edit health content can be found here. The edit box has a built-in citation tool to easily format references based on the PMID or ISBN.

  1. While editing any article or a wikipage, on the top of the edit window you will see a toolbar which says "cite" click on it
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We also provide style advice about the structure and content of medicine-related encyclopedia articles. The welcome page is another good place to learn about editing the encyclopedia. If you have any questions, please feel free to drop me a note. Doc James (talk · contribs · email) 22:44, 30 June 2019 (UTC)Reply

What does this have to do with trazodone? edit

Latest comment: 4 years ago3 comments2 people in discussion

Insomnia has been association with sleep-related disordered breathing.[1]

[2][3][4]

Doc James (talk · contribs · email) 22:44, 30 June 2019 (UTC)Reply

The full text of this https://journal.chestnet.org/article/S0012-3692(10)60302-9/fulltext does not mention trazadone. Refs should generally at least mention the topic they are about. Doc James (talk · contribs · email) 00:59, 1 July 2019 (UTC)Reply

To: Doc James

Why does it matter if these sources do not directly mention trazodone?

The paragraph I wrote was added to Trazodon'e section on insomnia to illustrate that a significant portion of those with chronic insomnia have disordered breathing as a causative factor for their insomnia. That first sentence then ties into the second, and third, and so on, to illustrate the interactions observed in individuals with insomnia being treated with trazodone. A lot of the 'side effects' in sleep medications are symptoms found in patients with disordered breathing and observed to resolve when the disordered breathing is treated. The psychiatric fields negligence in attending to the role non-hypoxic respiratory events has upon sleep fragmentation and alterations in sleep architecture has lead to a paucity of research directly evaluating the impact psychoactive medications have on sleep quality.

I am not sure why you are taking one sentence out of context like this. Nor of what benefit such behavior is to the integrity of the information on wikipedia. Here is the full paragraph:

Insomnia has a known association with sleep-related disordered breathing. [5][6][7][8][9]. "In our clinical practice and research experience, approximately 80% of patients reporting insomnia for >6 months also have SDB."[10] Autonomic dysfunction has been observed to occur in individuals with sleep-related disordered breathing: "Our data demonstrate, for the first time, that some subjects with UARS have low resting arterial BP, OI, and orthostatic hypotension (OH)."[11][12] Orthostatic hypotension is a known side effect of Trazodone.[13] "Falling down as a result of fainting (syncope) is a common complication in people with orthostatic hypotension."[14]. Clinical findings show syncope can respond favorably to the treatment of sleep-related disordered breathing.[15][16].

While I could understand criticism of the above paragraph you also erased this section:

Studies in animal models indicate trazodone can "impair sleep-dependent brain plasticity".[17].]

It directly studies trazodone and one of it's negative impacts to sleep. Sleep issues being one of Trazodone's primary off-label uses, it is directly relevant. Many of the most important studies in sleep science are animal studies because doing them in humans would be unethical. A good example is David Gozals study on cancer in rodents to determine the mechanisms by which sleep fragmentation causes cancer to become more prevalent and aggressive. Another good example is Harvold's Monkey experiments. A third example are the studies in rodents regarding the ability of ketosis to protect from hypoxia and improve oxygen efficiency. I'm not sure why you edited out everything. It honestly seems as if you take a cursory glance before taking action, and that is rather antithetical to engaging in a scientific process or relying upon an evidence-based paradigm. I am honestly curious what it is you're trying to accomplish.


MakesNotSense (talk) 17:01, 1 July 2019 (UTC)Reply

  1. ^ Wickwire, Emerson M.; Collop, Nancy A. (June 2010). "Insomnia and Sleep-Related Breathing Disorders". Chest. 137 (6): 1449–1463. doi:10.1378/chest.09-1485.
  2. ^ Suhalia E. Al-Jawder, Ahmed S. Bahammam. (2012). Comorbid insomnia in sleep-related breathing disorders: an under-recognized association. Sleep and Breathing. 16(2); 295-304.,
  3. ^ Amdo, Tshering & Hasaneen, Nadia & Gold, Morris & Gold, Avram. (2016). Somatic syndromes, insomnia, anxiety, and stress among sleep disordered breathing patients. Sleep and Breathing. 20. 10.1007/s11325-015-1296-6.
  4. ^ Wickwire, Emerson M. et al. (2010). Insomnia and Sleep-Related Breathing Disorders. CHEST. 137(6); 1449-1463.
  5. ^ Suhalia E. Al-Jawder, Ahmed S. Bahammam. (2012). Comorbid insomnia in sleep-related breathing disorders: an under-recognized association. Sleep and Breathing. 16(2); 295-304.,
  6. ^ Amdo, Tshering & Hasaneen, Nadia & Gold, Morris & Gold, Avram. (2016). Somatic syndromes, insomnia, anxiety, and stress among sleep disordered breathing patients. Sleep and Breathing. 20. 10.1007/s11325-015-1296-6.
  7. ^ Wickwire, Emerson M. et al. (2010). Insomnia and Sleep-Related Breathing Disorders. CHEST. 137(6); 1449-1463.
  8. ^ Johansson, P., Svensson, E., Alehagen, U., Jaarsma, T., & Broström, A. (2015). The contribution of hypoxia to the association between sleep apnoea, insomnia, and cardiovascular mortality in community-dwelling elderly with and without cardiovascular disease. European Journal of Cardiovascular Nursing, 14(3), 222–231. https://doi.org/10.1177/1474515114524072
  9. ^ Ulla Anttalainen, et al. (2018). Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comordibity in the European sleep apnea cohort (ESADA). Sleep and Breathing. 10.1007/s11325-018-1757-9.
  10. ^ Krakow, Barry et al. (2003). Relationships Between Insomnia and Sleep-Disordered Breathing. CHEST. 123(1); 311-313.
  11. ^ Guilleminault Christian, John L. Faul, Riccardo Stoohs. (2001). Sleep-disordered Breathing and Hypotension. Amer Jour Resp & Crit Care Med. 164(7); 1242-1247
  12. ^ de Godoy, L. B., Palombini, L. O., Guilleminault, C., Poyares, D., Tufik, S., & Togeiro, S. M. (2015). Treatment of upper airway resistance syndrome in adults: Where do we stand?. Sleep science (Sao Paulo, Brazil), 8(1), 42–48. doi:10.1016/j.slsci.2015.03.001
  13. ^ https://www.rxlist.com/trazodone/drugs-condition.htm
  14. ^ https://www.mayoclinic.org/diseases-conditions/orthostatic-hypotension/symptoms-causes/syc-20352548
  15. ^ Hamada E., Okamoto K., Okuda B. (2004) A case of pure autonomic failure (PAF) with sleep apnea syndrome (SAS) and successful treatment of dysautonomia with nasal continuous positive airway pressure (CPAP). Japanese Jour of Geriatrics. 41(2); 223-236
  16. ^ Floyd B. Willis, Amber L. Isley, Yonas E. Geda, Ali Shaygan, Luther Quarles, Paul A. Fredrickson. (2008). Resolution of Syncope With Treatment of Sleep Apnea. The Journal of the American Board of Family Medicine. 21(5); 466-468
  17. ^ Aton, Sara & Seibt, Julie & Bridi, Michelle & Coleman, Tammi & Shiraishi, Mia & Frank, Marcos. (2009). The Sedating Antidepressant Trazodone Impairs Sleep-Dependent Cortical Plasticity. PloS one. 4. e6078. 10.1371/journal.pone.0006078.
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