Laurennmichelle97

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Hello, Laurennmichelle97, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.

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If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 13:26, 26 January 2018 (UTC)

Hi!

It is very cool that you have been to so many different countries and that you can also play the harp!.Tsenft7 (talk) 05:10, 3 February 2018 (UTC)

So much traveling sounds like fun! I lived in a lot of different places as a child - California, Taiwan, the Netherlands, Colorado, and New Jersey - all before college. MMBiology (talk) 23:20, 3 February 2018 (UTC)

Outline

Ferroptosis

Give a general overview of what ferroptosis is, a general sense of how it occurs, and how it benefits(or not) the body “ferroptosis, an iron-dependent form of nonapoptotic cell death, was identified in cancer cells and mouse embryonic development (24–26). Ferroptosis is distinguishable from other forms of regulated cell death in that it does not require caspases (mediators of apoptosis and pyroptosis), ATP depletion or mitochondrial ROS generation (mediators of necroptosis), Bax/Bak (essential mediators of mitochondrial outer membrane permeabilization), or elevations in intracellular Ca2+ (26).”- Chen “Ferroptosis is associated with shrunken mitochondria (morphologically) and requires a unique set of genes” - Li

How does ferroptosis differ from apoptosis or other types of cell death - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885741/

-Apoptosis

• Morphological changes
• Cascade of reactions regulated by caspases
• Specifically, activation of a family of intracellular cysteine proteases which cleave their substrates at aspartic acid residues, known as caspases for Cysteine Aspartyl-specific Proteases.

-Ferroptosis

• Induced by blocking intracellular mechanisms from occurring
• Iron dependent

-Both are capable of being inhibited

• Have different inhibitor proteins

-Briefly mention other types of cell death:

• Nectroptosis
• Autophagy

Ferroptosis in the nervous system

-Activating transcription factor 4 (ATF4)

• Presence in glioma cells
• ATF4 depletion renders cells susceptible for ferroptosis

Resources Chen, D et al. “ATF4 Promotes Angiogenesis and Neuronal Cell Death and Confers Ferroptosis in a xCT-Dependent Manner.” Oncogene 36.40 (2017): 5593–5608. PMC. Web. 20 Feb. 2018. Li, Qian et al. “Inhibition of Neuronal Ferroptosis Protects Hemorrhagic Brain.” JCI Insight 2.7 (2017): e90777. PMC. Web. 20 Feb. 2018. Reed, John C. “Mechanisms of Apoptosis.” The American Journal of Pathology 157.5 (2000): 1415–1430. Print. — Preceding unsigned comment added by Laurennmichelle7 (talk • contribs) 16:11, 23 February 2018 (UTC)