User talk:Kwall005/sandbox
Anal pore One issue of this article is that it does not cite any sources. I would look into trying to find at least one source that supports the information stated in this article. I would also look into inserting an image that can help a reader who is not familiar with cellular anatomy. This article may also be confusing to readers with how the authors states one of their sentences. I would attempt to reword the sentence so the reader does not have to question what the author is trying to convey.Kwall005 (talk) 14:57, 18 October 2016 (UTC)
This gene is located at chromosome 19q13.2, it codes for one of three isoenzymes. [1]The other two enzymes being ITPKA and ITPKB. The ITPK enzymes are used to phosphorylate IP3. ITPKC is involved in the Ca(2+)/NFAT pathway negatively regulating T cell activation. [2]
A mutation in this gene occurs through a single-nucleotide polymorphism. When a mutation occurs the gene does not produce a functioning enzyme, meaning it will no longer be effective in negatively regulating T cells. Leading to overly active T cells, having this mutation in ITPKC is correlated to the increased risk of developing symptoms.[3]Kwall005 (talk) 12:39, 1 November 2016 (UTC) Kwall005 (talk) 17:47, 5 November 2016 (UTC)
- ^ Onouchi, Yoshihiro; Gunji, Tomohiko; Burns, Jane C; Shimizu, Chisato; Newburger, Jane W; Yashiro, Mayumi; Nakamura, Yoshikazu; Yanagawa, Hiroshi; Wakui, Keiko; Fukushima, Yoshimitsu; Kishi, Fumio; Hamamoto, Kunihiro; Terai, Masaru; Sato, Yoshitake; Ouchi, Kazunobu; Saji, Tsutomu; Nariai, Akiyoshi; Kaburagi, Yoichi; Yoshikawa, Tetsushi; Suzuki, Kyoko; Tanaka, Takeo; Nagai, Toshiro; Cho, Hideo; Fujino, Akihiro; Sekine, Akihiro; Nakamichi, Reiichiro; Tsunoda, Tatsuhiko; Kawasaki, Tomisaku; Nakamura, Yusuke; Hata, Akira (5 November 2016). "ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms". Nature genetics. 40 (1): 35–42. doi:10.1038/ng.2007.59. ISSN 1061-4036.
- ^ Reference, Genetics Home. "ITPKC gene". Genetics Home Reference. Retrieved 5 November 2016.
- ^ Yoon, Kyung Lim (5 November 2016). "Update of genetic susceptibility in patients with Kawasaki disease". Korean Journal of Pediatrics. 58 (3): 84–88. doi:10.3345/kjp.2015.58.3.84. ISSN 1738-1061. Retrieved 5 November 2016.