Immcarle7

Assignment 9

Peer reviewer feedback:

Opening paragraph: The context for the remaining sections of the article is well set up, especially by introducing their relationship to T reg cells and their role in other immunological system functions. Alluding to experimental evidence also provides context tot he research and the nature of the field. The second sentence is a little confusing to me about the signals that encourage one also discourage the other. Maybe its as simple as terminology/ word choice changes?

Grammar/punctuation: I have emailed you a copy of your text corrected for grammar and punctuation.

Technical/appropriate audience: I think the lead, function, and Th17 cells in disease are not too technical. They set up ideas and define terms that allow reader to follow through easily. The more technical sections are differentiation, role of Th17 cells in autoimmune disorders, and loss of Th17 cells in HIV pathogenesis. It is harder to follow the description in these paragraphs, but as an Immunology student I have a lot of appreciation for them!. You can consider adding a citation to the last sentence of the differentiation paragraph, even if you did not write it yourself. I have found it helpful to cite in brackets, the other wikipedia articles referring to the vocabulary words you used. I would also keep defining more terms, like interleukin, for example.

Recent citations: You have well over 5 current citations. They are all from the past decade or so. Especially your Loss of Th17 cells in HIV pathogenesis section, where you have research from the past five years or so.

Copy-edit: I have emailed you the word document with some of the my grammar, punctuation, and other minor edits and suggestions. Hopefully these are helpful, let me know if you have any questions!

3-5 new paragraphs/1-3 paragraph modifications: It seems to me like you contributed most to the Loss of Th17 cells in HIV pathogenesis sections. You have 3-4 paragraphs here. I can also see in your view history that you have made significant change stop the lead sections and some changes to the differentiation and function sections. — Preceding unsigned comment added by Immcarl17 (talk • contribs) 08:29, 25 February 2016 (UTC)

Immcarl17 (talk) 15:05, 25 February 2016 (UTC)

Assignment 4.5: New Final Article Choice

I'm actually going to edit the Th17 page.

Th17 overview

• Guglani, L. & Khader, S. A. Th17 cytokines in mucosal immunity and inflammation. Current Opinion in HIV and AIDS 5, 120–127 (2010).
• Miossec, P. & Kolls, J. K. Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov 11, 763–776 (2012).
• Noack, M. & Miossec, P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 13, 668–677 (2014).

Th17 in HIV

• Bixler, S. L. & Mattapallil, J. J. Loss and dysregulation of Th17 cells during HIV infection. Clin. Dev. Immunol. 2013, 852418 (2013).
• Hartigan-O'Connor, D. J., Hirao, L. A., McCune, J. M. & Dandekar, S. Th17 cells and regulatory T cells in elite control over HIV and SIV. Current Opinion in HIV and AIDS 6, 221–227 (2011).

Primary Papers:

• Alvarez, Y. et al. Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands. Journal of Virology 87, 10843–10854 (2013).
• Falivene, J. et al. Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8(+) T-cell responses and disease progression. Sci Rep 5, 11511 (2015).
• Pallikkuth, S. et al. Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21. PLoS Pathog 9, e1003471–16 (2013).

Assignment 4: Final Article Choice

I will be adding information about the role of mucus in the gut. Mucus is an essential part of fighting inflammation in the gut.

Bibliography

Structure:

• Allen, A., Hutton, D. A. & Pearson, J. P. The MUC2 gene product: a human intestinal mucin. Int. J. Biochem. Cell Biol. 30, 797–801 (1998).
• Johansson, M. E. V., Larsson, J. M. H. & Hansson, G. C. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc. Natl. Acad. Sci. U.S.A. 108 Suppl 1, 4659–4665 (2011).
• Loonen, L. M. P. et al. REG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum. Mucosal Immunol 7, 939–947 (2014).

Immunological role:

• Johansson, M. E. V. et al. Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS ONE 5, e12238 (2010).
• Shan, M. et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342, 447–453 (2013).

Potential Choices for Article to Edit

HIV Tropism: This page on HIV tropism hasn't been updated since 2011. The term tropism refers to the types of cells a given virus can enter and replicate it. HIV generally enters cells through receptor-mediated endocytosis, a process that has some similarity to phagocytosis.

MHC restriction: This is an important part of antigen recognition by T cells. This article does not cite any sources or discuss causes of MHC restriction. It could also use some more information about cases where MHC restriction does not occur.

Mucus: Mucus is a very important part of gut immunity and maintaining homeostasis between immune cells and gut bacteria. There's little to nothing about this important intestinal role of mucus in this wikipedia article!!!

Welcome!

Hello, Immcarle7, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.

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If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 23:27, 11 January 2016 (UTC)

Welcome!

Hi Immcarle7! Just wanted to say hi. Immcarle23 (talk) 14:11, 13 January 2016 (UTC)

Hi Hi Immcarle7! Immcarle4 (talk) 16:58, 13 January 2016 (UTC)