Immcarle22
Welcome! edit
Hello, Immcarle22, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.
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If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 01:28, 13 January 2016 (UTC)
Introducing myself edit
Hi I'm Shraddha. I am in your Immunology class. I am hopeful that this will be a great platform to learn cool wiki things and share immunology info with my classmates. You can communicate with me on my talk user page, Immcarl17 (talk) 02:03, 13 January 2016 (UTC).
Classical complement peer edits edit
Lead section / Overview
It'd be great if you could add some kind of a hook that illustrates the magnitude of importance of complement with some information about what happens to people when they don't have a functional classical complement pathway, and also it would be cool to talk about how effective complement is as an inflammatory cascade. Also related to that point--your lead section should include an overview of complement and an outline of the whole article, so you could combine those sections and also touch on clinical significance.
Initiation and Signal Amplification
It would be helpful to talk about what exactly "C1" (and other involved factors) is and where it comes from to contextualize this info--for example, you and I know it's a protein but a reader might not. Also, what structures of a microbe could C1 bind to specifically? How does C-Reactive protein start off the signaling cascade? Also I don't think "microbic" is a word.
Steps leading to C3-convertase
Lol @ the figure where "some labels are in Polish"--I bet it wouldn't be hard to find a better figure illustrating the lead-up to C3-convertase, or at least write a better figure caption describing what all is happening in steps 1-7 (which you've already partially done). I think we've all lost sight of this a little bit but since we're writing for a general non-scientist audience, we should use less jargon and focus on the big picture if possible! If you could explain the significance of what all these cleaved particles go on to do I think it would make the whole sequence more meaningful. I like the figure used here better: https://en.wikipedia.org/wiki/Complement_system#Classical_pathway and perhaps some of the information would be useful to you as well.
Clinical Significance
-All of this information is so interesting--I would love to know more about what parts of complement are implicated, which would also help to make all the alphabet soup in the previous section more meaningful. -Italicize scientific names
Hope that helps! Immcarle23 (talk) 03:13, 27 February 2016 (UTC)