User talk:Bradley3/sandbox
Comments
edit-Remove “potential to form” in beginning of second paragraph
-“a high sequence-dependent, predicted propensity” –This needs to be reworded
- Don’t need to define nucleosomes, just link to the wiki page
- “Nucleosomes are unlikely to form Z-DNA”. Replace with: “Z-DNA is unlikely to form in nucleosomes”
- “This regulates the rate of transcription in certain regions of DNA”: Is this known conclusively or just hypothesized to?
--MichaelChiorazzo (talk) 22:08, 11 November 2017 (UTC)
-the entire second paragraph doesn't seem to have a source. It contains some good information about Z-DNA but without a source it doesn't hold much weight.
"In mammalian cells, Z-DNA was found to produce large genomic fragment deletions due to chromosomal double-strand breaks, both genetic modifications which have been linked to the gene translocations in human diseases such as leukemia and lymphoma"
-I would change out the word produce for cause; produce almost sounds like its something that happens no matter what. (Which maybe it is I suppose?). I also think the the last half of the sentence is kind of difficult to read. I might just go ahead and make it another sentence. Something like "Both of these genetic modifications have been linked to..." just for ease of readability.
"The toxic effect of ethidium bromide on trypanosomas is caused by shift of their kinetoplastid DNA to Z-form"
-A wiki link to trypanosomas would be helpful. I actually had to google it (and subsequently read the wikipedia page about it) to understand what this sentence was intending to say
-This sentence also feels like a weird jump. If you are using subheadings, I would put it under it's own so it doesn't seem so out of the blue and give some more description of what the toxic effect is and why it matters
Racheldfray (talk) 12:10, 13 November 2017 (UTC)
However, while supercoiling is associated with both transcription and DNA replication (I suggest changing wording to "DNA replication and transcription"), Z-DNA formation is primarily linked to the rate of transcription (change to "transcription rate")
Nucleosomes (regions of DNA tightly wrapped around histone proteins) are unlikely to form on Z-DNA but often occur after a Z-DNA forming sequence. (instead of defining nucleosomes, add the link for the wikipedia page).
This regulates the rate of transcription in certain regions of DNA. (Vague what you are referring to as "this")