User talk:Antknee1/Adenovirus early region 1A

Planned Edits:

Removal of source #6, which is not relevant to the topic nor used appropriately to substantiate the claim that "After viral infection, [the two major proteins encoded by E1A in Ad5] stimulate expression of other viral genes and can either enhance or repress expression of cellular genes."

Addition of 6 Sections: Summary, Transcription, Translation, Protein Product Structures, Role in Viral Life Cycle, and Effects on Host

Antknee1 (talk) 20:45, 5 October 2020 (UTC)

MLibrarian Review

Please link cAMP to Cyclic adenosine monophosphate and before using abbreviation, please always spell out the full name. Look for other things to hyperlink. It is a good expansion to the article!MLibrarian (talk) 16:08, 15 October 2020 (UTC)

Adenovirus early region 1A Peer Review 1

I would want to point out that generally genes are italicized whereas proteins remain unformatted. Also, I suggest the content under the Transcription subtopic (and possibly other subtopics) could use some Wikipage links; for example, alternative splicing has well-developed Wikipage which when linked, can make that statement you typed very concise for those who know about it. And for those who don't, hovering the cursor over the link will give them a gist of it.

I like the explanation given under Effects on Host Cell. Similar to how your group laid out the oncogenesis of E1A, I was wondering if you'll be working on the addition of ways by which it acts as a tumor suppressor gene in a host cell.

Under the Translation subtopic, is there a reason why you have parenthesis around the R in the second paragraph for the 289R protein and not the other proteins?

Phylix690 (talk) 22:43, 13 October 2020 (UTC)

Adenovirus early region 1A Peer Review 1

I like your explanation under the transcription section. Seems thorough to me. I think more information could be added to the beginning introduction paragraph in order to summarize or give the main points of the wiki page in addition to the broad overview of the Adenovirus in the beginning.

In the second paragraph of the Translation section, I think more information could be added on how specifically the protein resudies regulate the viral genes and the infected host cell.

In the Structure of Protein Products section, this section feels like it is jumping around and could flow better. If possible, I think a diagram made on powerpoint or another platform would be helpful to view the structure or map out where the conserved regions are.

I think your Effects on Host Cell section is more detailed and explained very well.

Miraprabhu (talk) 14:47, 14 October 2020 (UTC)miraprabhu

==jennaconnolly Peer Review== Adenovirus early region 1A

Under transcription, should you expand upon/add relevant context to what a “linear DNA molecule” is? Even to those that are familiar with the field might be unfamiliar with non helical dsDNA, similar to how you defined alternative/differential splicing in a concise manner.

Under structure of protein products, why is the intrinsic structure of E1A highly disordered? Is there any helpful information you could add here?

I like the description of the effects of the host cell. I suggest expanding on the mechanisms in which the products interfere with host immunity and what effects this could propagate in the host.

I did not catch any minor edits or grammatical/syntax errors

ColorMeAfrican Peer Review 1

To flesh out this article, I would consider including why it is considered an oncogene and how it can behave as a tumor suppressor gene

I recommend including images pertaining to your subject to break up the text.

In the transcription section, I found the last sentence which discusses the similarities of the protein EA1 codes for to be unnecessary.

It is necessary. We were trying to point out that the structures vary because of how the gene is spliced. Which means any two proteins could have similar AA sequences. Garhingh (talk) 13:08, 22 October 2020 (UTC)

I believe you did a good job of supporting the vast majority of your claims with links to pertinent science articles.

There were a few words which have related wikipedia pages that had not been linked yet. A few include "conserved regions/sequences," "cis-regulatory element," and "transactivation." — Preceding unsigned comment added by ColorMeAfrican (talk • contribs) 17:29, 15 October 2020 (UTC)

Meredith's comments

This is looking really good so far. I think figures would be a huge help here to demonstrate some of the broader ideas - like the structure of the gene, or the protein product. A lead paragraph would also be very welcome - especially to help out average readers who are just looking for a brief overview. It looks like you have some good plans for the rest of the article and I look forward to seeing the final product. Well done! Purchalm (talk) 16:30, 15 October 2020 (UTC)