TBR1 Proposal edit
Definition edit
-T-box Brain Protein, TBR1 for short, also known as T-Brain 1, and TES-56
-made up of 6 exons
-transcription factor expressed in postmitotic projection neurons
-Classification Group: Beta-Hairpin-Ribbon-Group, Family: Transcription Factor T-Domain
Function edit
-developmental process
-normal brain development
-neuronal differentiation
-transition from intermediate progenitor cell to post mitotic neuron
-regulation of neurons in developing neocortex
History edit
-identified in 1995
Relation to Other Genes edit
-Human gene TBR1 has an orthologous gene in zebrafish
-TBR1 is downstream of Pax6
-TBR1 is a promoter of Auts2
-TBR1 represses Fezf2
-Af9 associates with transcriptional start site of TBR1
-TBR1 forms T-box gene family with TBR2 and T-BET
-CASK is a coactivator of TBR1
Experimentation/Studies in Other Species edit
-TBR1 is involved in frontal identity
-transcription factor sequence: Pax6 → Tbr2 → Tbr1
-Similar protein in mice involved in cortical development
-Expressed in mouse CNS
-Appears to be restricted to glutamatergic neurons in mice
Current Research edit
References edit
Bedogni, Francesco et al. "Tbr1 Regulates Regional and Laminar Identity of Postmitotic Neurons in Developing Neocortex." PMC. 6 July 2010. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919950/?tool=pmcentrez>.
Büttner, Nicole et al. "Af9/Mllt3 Interferes with Tbr1 Expression through Epigenetic Modification of Histone H3K79 during Development of the Cerebral Cortex." PMC. 13 Apr. 2010. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872432/?tool=pmcentrez>.
Englund, C et al. "Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex." PMC. 5 Jan. 2005. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pubmed/15634788>.
Han, Wenqi et al. "TBR1 Directly Represses Fezf2 to Control the Laminar Origin and Development of the Corticospinal Tract." PMC. 15 Feb. 2011. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041103/?tool=pmcentrez>.
Hevner, Robert et al. "Human TBR1." Wasserman Lab Online Tools. Transcription Factor Encyclopedia, 4 Aug. 2010. Web. 27 Sept. 2011. <http://www.cisreg.ca/cgi-bin/tfe/articles.pl?tfid=156>.
"Human Gene TBR1." UCSC Genome Browser Home. UniProt Consortium, 2009. Web. 27 Sept. 2011. <http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human>.
Division of Workload edit
We have decided to meet Tuesdays at 2 to work on our project. We think that this is the best way for all of us to discuss and understand fully the topic so that we can create a cohesive article. We recognize that we have not provided examples of current research. This is an area we plan to further develop as we go forth in this project.