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The PER3 gene encodes the period circadian protein homolog 3 protein in humans.[1] PER3 is a paralog to the PER1 and PER2 genes.
History
editThe Per3 gene was independently cloned by two research groups (Kobe University School of Medicine and the Harvard Medical School) who both published their discovery in June 1988.[2][3] The mammalian Per3 was discovered by searching for homologous cDNA sequences to Per2. The amino acid sequence of the mouse PERIOD3 protein (mPER3) is between 37-56% similar to the other two PER proteins.[3][2]
Function
editThis gene is a member of the Period family of genes. It is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN), the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the SCN continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the SCN.[4] Numerous studies have shown that PER1 and PER2 are necessary for molecular timekeeping and light responsiveness in the master circadian clock in the SCN, but little data is shown on the concrete function for PER3. PER3 was found to be important for endogenous timekeeping in specific tissues and those tissue-specific changes in endogenous periods result in internal misalignment of circadian clocks in Per3 double knockout (-/-) mice.[5]
- ^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM (December 1997). "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei". Neuron. 19 (6): 1261–9. doi:10.1016/S0896-6273(00)80417-1. PMID 9427249.
- ^ a b Takumi T, Taguchi K, Miyake S, Sakakida Y, Takashima N, Matsubara C, Maebayashi Y, Okumura K, Takekida S, Yamamoto S, Yagita K, Yan L, Young MW, Okamura H (1998). "A light-independent oscillatory gene mPer3 in mouse SCN and OVLT". The EMBO Journal. 17 (16): 4753–9. doi:10.1093/emboj/17.16.4753. PMC 1170804. PMID 9707434.
- ^ a b Cite error: The named reference
Zylka_1998was invoked but never defined (see the help page). - ^ "Entrez Gene: PER3 period homolog 3 (Human)".
- ^ Pendergast, JS; Niswender, KD; Yamazaki, S (2012). "Tissue-specific function of Period3 in circadian rhythmicity". PloS one. 7 (1): e30254. doi:10.1371/journal.pone.0030254. PMID 22253927.
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