Rtian96

Peer-Review Comments from Chloe Malcolm

Very good job and interesting topic! I felt that the amount of information provided was perfect to help me understand the big picture of mitochondrial biogenesis.

I am not sure if it is just because I am not very familiar with Mitochondrial biogenesis, but I am not sure what the "copy number" refers to? I was also a little confused about what Mfn 1, Mfn 2, Opa1, and AMPK are? It may be beneficial to explain to what the copy number is so the reader understands the importance of it, and define or explain the abbreviations.

The Aging section was extremely interesting, however I thought it was a little unclear about what telomeres were and what their significance is to the topic. For example, the article talks about telomeres and how they are associated with impaired mitochondrial biogenesis, how exactly are they associated?

There is no use of media within the article, however I think it would be a great idea for the reader to be able to refer to a picture in order to help clear up any confusion on the scientific information.

The sources you have used for the article are very credible and state updated information. There are also a good number of sources cited for your article which makes the overall article seem reliable. However, I noticed that throughout the article at the end of paragraphs there is not always a source cited? I think if everything in the article is cited it would make the article more reliable and well rounded.

I also noticed many words throughout your article that could be linked to other wikipedia articles. This can also be very helpful to readers with little background in science. They can then go to the other pages to read and get some clarity.

I really liked your organization of the article, all information was under the appropriate heading. The article also flowed extremely well, so overall great job!

I hope these comments help. Good Luck

Peer-Review Comments from Darien Azani

1. What does he article do well?

Your article summarizes mitochondrial biogenesis very well and in a clear and concise manner. I was able to read the entire article without needing to stop and reread over any confusing sentences. After reading your page I feel like I have a good understanding of what mitochondrial biogenesis is and why it happens. You have found a great balance between presenting good, scientific information, in a very easy to understand way. I'm very impressed with your writing! Great job 

2. What parts of the article could be improved?

I think what this article needs most is citations and links to other pages. Many of the paragraphs have several sentences before coming to one that is cited which could potentially be an issue with Wikipedia. 

3. What's the most important thing the author can do to improve the article?

The most important thing you could do would be to go back and add citations where needed so we know that the information has come from credible sources that have been thoroughly vetted. Other than that I don't think there's anything I see wrong with your article. 

4. Did you find anything about this article that could be applied to your own?

I definitely think that my article could improve on how clear and concise the information is presented. Your article has a level of flow and ease of reading that I think everyone could apply to their own article. I think you definitely hit the sweet spot between depth of information and ease of reading! 

Overall great job!! 

Darien Azani

TOPIC: Mitochondrial biogenesis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883043/ - Regulation of Mitochondrial Biogenesis

https://www.ncbi.nlm.nih.gov/pubmed/18430751 - Transcriptional Control of Mitochondrial Biogenesis: the central role of PGC-1 alpha

https://www.ncbi.nlm.nih.gov/pubmed/20649548 - Redefining the role of mitochondria in exercise: a dynamical remodeling

https://www.ncbi.nlm.nih.gov/pubmed/22146081 - Redox regulation of mitochondrial function

https://www.ncbi.nlm.nih.gov/pubmed/21543634 - Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle.

https://www.ncbi.nlm.nih.gov/pubmed/20933024 - Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100651/ - Mitochondria and PGC-1α in Aging and Age-Associated Diseases