Raisa.karim

I will be using the following space to work on expanding the iontropic GABA receptors page.

Ionotropic GABA receptors

This is a neuromuscular junction. There is a presynaptic unit (axon), a synapse and a postsynaptic unit (dendrite). Neurotransmitters are released into the synapse.

The neuromuscular junction in the CNS can be composed of a presynaptic unit located at an axon terminal with synaptic vesicles and a postsynaptic unit located at a dendrite. Neurotransmitters are chemical molecules that are released from a presynaptic unit into the synapse and received by the postsynaptic unit, resulting in a biological and electrophysiological effect. The two main types of neurotransmitters are amino acid transmitters and GABA transmitters. The release of and binding of glutamate, an amino acid transmitter, to its respective receptor manifests in an excitatory postsynaptic potential (EPSP). On the other hand, the release and binding of gamma-amino butyric acid (GABA) to the GABA receptor results in an inhibitory postynaptic potential (IPSP). The ability of the GABA receptor function rests on its molecular structure of multiple binding sites and conductance levels. These receptors are prevalent in interneurons relaying messages among various regions of the brain.

Classification of Ligand-Gated Ion Channels: iGABARs fall under the Cys-Loop receptors.

The two types of GABA receptors are the GABA_A and GABA_B receptors. The pentameric GABA_A receptors are ionotropic, meaning that upon binding with the ligand their biological and electrophysiological effect is carried out through the conductance of ions. This is why the physiological makeup for GABA_A receptors differs from GABA_B in that they are ligand-gated ion channels. The chloride-ion gated channels facilitate the inhibitory effect through the influx of chloride ions. However, GABA_B receptors are metabotropic meaning they utilize a G-protein coupled mechanism. Since the G-protein is a heterodimeric molecule, the separation and phosphorylation of its parts result in a signal cascade, resulting in a more steady but amplified response.   

Earlier a third type of GABA receptor was discovered and named GABA_C, but recently it has been categorized as a sub-type of the GABA_A receptor. Thus, the iontropic GABA receptors consist of the GABA_A receptor and the GABA_A-ρ receptor.There are pharmalogical implications in understanding the molecular structure and function of these ionotropic receptors. Since they are targeted by neuroactive drugs, this characteristic is exploited in order to deduce their molecular structure and function in the CNS. For example, GABA_A receptors respond to neuroactive drugs like bensodiazepines. Normally increasing a neuron's permeability to chloride ions results in inhibition; bensodiazepines further propagate this event ensuring inhibition, serving as an indirect factor. Armed with the knowledge of chloride ion permeability leading to inhibition, it is important to note that ethanol and barbiturates can directly increase the influx of chloride ions resulting in inhibition. Further characterization of the allosteric modulations of the active sites in the ionotropic gives insight on new treatments and nervous system disorders, such as panic disorder.